1. Tumor cell biology

  • Molecular mechanism of invasion and metastasis of colorectal and breast carcinomas.
  • Molecular interaction between fragmented hyaluronan and CD44.
  • Hyaluronan-induced cell motility. (activation of RhoGTPases and assembly of cytoskeletons)
  • Molecular mechanism of epithelial-mesenchymal transition.

    • 2. Stem cell biology

  • Cell-cell and cell-matrix interaction of stem cell. (Notch signaling and function of CD44)

    • 3. Signal transduction

  • Hyaluronan-induced signaling.
  • Notch signaling: function of mastermind. (Knockout mice)

    • 4. Live cell imaging

    5. Human pathology