業績

 【原著論文】

2021

Y. Ito, T. Sasaki, Y. Li, T. Tanoue, Y. Sugiura, AN. Skelly, W. Suda, Y. Kawashima, N. Okahashi, E. Watanabe, H. Horikawa, A. Shiohama, R. Kurokawa, E. Kawakami, H. Iseki, H. Kawasaki, Y. Iwakura, A. Shiota, L. Yu, J. Hisatsune, H. Koseki, M. Sugai, M. Arita, O. Ohara, T. Matsui, M. Suematsu, M. Hattori, K. Atarashi, M. Amagai, K. Honda. Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation. Cell reports, 2021, 35(4)109052-109052

M. Kiuchi, A. Onodera, K. Kokubo, T. Ichikawa, Y. Morimoto, E. Kawakami, N. Takayama, K. Eto, H. Koseki, K. Hirahara, T. Nakayama. The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. The Journal of experimental medicine, 2021, 218(4)

S. Sakao, E. Kawakami, H. Shoji, A. Naito, H. Miwa, R. Suda, TJ. Sanada, N. Tanabe, K. Tatsumi. Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension. Molecular medicine reports, 2021, 23(4)

AP. d. Groot, Y. Saito, E. Kawakami, M. Hashimoto, Y. Aoki, R. Ono, I. Ogahara, S. Fujiki, A. Kaneko, K. Sato, H. Kajita, T. Watanabe, M. Takagi, D. Tomizawa, K. Koh, M. Eguchi, E. Ishii, O. Ohara, LD. Shultz, S. Mizutani, F. Ishikawa. Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia. EBioMedicine, 2021, 64, 103235-103235

T. Inoue, R. Shinnakasu, C. Kawai, W. Ise, E. Kawakami, N. Sax, T. Oki, T. Kitamura, K. Yamashita, H. Fukuyama, T. Kurosaki. Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal. The Journal of experimental medicine, 2021, 218(1)

M. Kato, K. Ikeda, T. Sugiyama, S. Tanaka, K. Iida, K. Suga, N. Nishimura, N. Mimura, T. Kasuya, T. Kumagai, H. Furuya, T. Iwamoto, A. Iwata, S. Furuta, A. Suto, K. Suzuki, E. Kawakami, H. Nakajima. Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis. PloS one, 2021, 16(5) e0252116

 

2020 

Keita Koseki, Hiroshi Kawasaki, Toru Atsugi, Miki Nakanishi, Makoto Mizuno, Eiji Naru, Tamotsu Ebihara, Masayuki Amagai, Eiryo Kawakami:Assessment of skin barrier function using skin images with topological data analysis.:NPJ systems biology and applications 6(1) 40 - 40 2020

Masashi Fujita, Xiaoxi Liu, Yusuke Iwasaki, Chikashi Terao, Keijiro Mizukami, Eiryo Kawakami, Sadaaki Takata, Chihiro Inai, Tomomi Aoi, Misaki Mizukoshi, Kazuhiro Maejima, Makoto Hirata, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Kiwamu Akagi, Koichi Matsuda, Hidewaki Nakagawa, Yukihide Momozawa:Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.:Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020

Tiffany Amariuta, Kazuyoshi Ishigaki, Hiroki Sugishita, Tazro Ohta, Masaru Koido, Kushal K Dey, Koichi Matsuda, Yoshinori Murakami, Alkes L Price, Eiryo Kawakami, Chikashi Terao, Soumya Raychaudhuri:Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.:Nature genetics 52(12) 1346 - 1354 2020

Keijiro Mizukami, Yusuke Iwasaki, Eiryo Kawakami, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Mikiko Endo, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami, Hidewaki Nakagawa, Amanda B Spurdle, Yukihide Momozawa:Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.:EBioMedicine 60 103033 - 103033 2020

Eiryo Kawakami:[Health and Medical Revolution Driven by Artificial Intelligence].Gan to kagaku ryoho. Cancer & chemotherapy 47(10) 1399 - 1404 2020

Hirofumi Aso, Shumpei Nagaoka, Eiryo Kawakami, Jumpei Ito, Saiful Islam, Benjy Jek Yang Tan, Shinji Nakaoka, Koichi Ashizaki, Katsuyuki Shiroguchi, Yutaka Suzuki, Yorifumi Satou, Yoshio Koyanagi, Kei Sato:Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo.:Cell reports 32(2) 107887 - 107887 2020

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew-Kee Low, Yukinori Okada, Chikashi Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, Ken Suzuki, Kaoru Ito, Satoshi Koyama, Kouichi Ozaki, Shumpei Niida, Yasushi Sakata, Yasuhiko Sakata, Takashi Kohno, Kouya Shiraishi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Ikuyo Kou, Toshihiro Tanaka, Hidewaki Nakagawa, Akari Suzuki, Tomomitsu Hirota, Mayumi Tamari, Kazuaki Chayama, Daiki Miki, Masaki Mori, Satoshi Nagayama, Yataro Daigo, Yoshio Miki, Toyomasa Katagiri, Osamu Ogawa, Wataru Obara, Hidemi Ito, Teruhiko Yoshida, Issei Imoto, Takashi Takahashi, Chizu Tanikawa, Takao Suzuki, Nobuaki Sinozaki, Shiro Minami, Hiroki Yamaguchi, Satoshi Asai, Yasuo Takahashi, Ken Yamaji, Kazuhisa Takahashi, Tomoaki Fujioka, Ryo Takata, Hideki Yanai, Akihide Masumoto, Yukihiro Koretsune, Hiromu Kutsumi, Masahiko Higashiyama, Shigeo Murayama, Naoko Minegishi, Kichiya Suzuki, Kozo Tanno, Atsushi Shimizu, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Hirokazu Uemura, Keitaro Tanaka, Mariko Naito, Makoto Sasaki, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Yoshinori Murakami, Yusuke Nakamura, Soumya Raychaudhuri, Johji Inazawa, Toshimasa Yamauchi, Takashi Kadowaki, Michiaki Kubo, Yoichiro Kamatani:Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.:Nature genetics 52(7) 669 - 679 2020

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A. Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki:Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity:Nature Immunology 2020

Kiwako Yamamoto-Hanada, Eiryo Kawakami, Mayako Saito-Abe, Miori Sato, Hiroshi Mitsubuchi, Masako Oda, Takahiko Katoh, Masafumi Sanefuji, Shouichi Ohga, Mari Kuwajima, Nathan Mise, Akihiko Ikegami, Fujio Kayama, Ayako Senju, Masayuki Shimono, Koichi Kusuhara, Shin Yamazaki, Shoji F Nakayama, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya:Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study.:Cytokine 130 155051 - 155051 2020

Hitoshi Inokawa, Yasuhiro Umemura, Akihiro Shimba, Eiryo Kawakami, Nobuya Koike, Yoshiki Tsuchiya, Munehiro Ohashi, Yoichi Minami, Guangwei Cui, Takuma Asahi, Ryutaro Ono, Yuh Sasawaki, Eiichi Konishi, Seung-Hee Yoo, Zheng Chen, Satoshi Teramukai, Koichi Ikuta, Kazuhiro Yagita:Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.

Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, Nobuyuki Udagawa, Shintaro Sato, Tsuneyasu Kaisho, Toshihiko Iwanaga, Koji Hase:Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.:Nature communications 11(1) 234 - 234 2020

 

2019

Terao C, Momozawa Y, Ishigaki K, Kawakami E, Akiyama M, Loh PR, Genovese G, Sugishita H, Ohta T, Hirata M, Perry JRB, Matsuda K, Murakami Y, Kubo M, Kamatani Y:GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation:Nature communications 2019

Kawakami E, Tabata J, Yanaihara N, Ishikawa T, Koseki K, Iida Y, Saito M, Komazaki H, Shapiro JS, Goto C, Akiyama Y, Saito R, Saito M, Takano H, Yamada K, Okamoto A;Application of Artificial Intelligence for Preoperative Diagnostic and Prognostic Prediction in Epithelial Ovarian Cancer Based on Blood Biomarkers.Clinical cancer research : an official journal of the American Association for Cancer Research 2019

Ono R, Watanabe T, Kawakami E, Iwasaki M, Tomizawa-Murasawa M, Matsuda M, Najima Y, Takagi S, Fujiki S, Sato R, Mochizuki Y, Yoshida H, Sato K, Yabe H, Kato S, Saito Y, Taniguchi S, Shultz LD, Ohara O, Amagai M, Koseki H, Ishikawa F;Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.EBioMedicine 2019

 

2018 

Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosaki T., T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.,Immunity, 48, 702-715, e4, 2018

Fujimoto H, Saito Y, Ohuchida K, Kawakami E, Fujiki S, Watanabe T, Ono R, Kaneko A, Takagi S, Najima Y, Hijikata A, Cui L, Ueki T, Oda Y, Hori S, Ohara O, Nakamura M, Saito T, Ishikawa F., Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1+ T Cells in Human Colorectal Cancer., The Journal of Immunology, 200, 3291-3303, 2018

Miyai T, Takano J, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T., Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells., Genes Dev., 32, 112-126, 2018

Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H, Ohmura K, Myouzen K, Ishigaki K, Nakashima R, Hosono Y, Tsuboi H, Kawasumi H, Iwasaki Y, Kajiyama H, Horita T, Ogawa-Momohara M, Takamura A, Tsunoda S, Shimizu J, Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K., Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis., Annals of the rheumatic diseases, annrheumdis-2017-212149, 2018  

 

2017 

Kawakami E, Adachi N, Senda T, Horikoshi M., Leading role of TBP in the Establishment of Complexity in Eukaryotic Transcription Initiation Systems., Cell Reports, 21, 3941-3956, 2017

Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, Imanishi T, Ginhoux F, Taniuchi I., Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling., J. Exp. Med., 214, 2933-2946, 2017

Hayatsu N, Miyao T, Tachibana M, Murakami R, Kimura A, Kato T, Kawakami E, Endo TA, Setoguchi R, Watarai H, Nishikawa T, Yasuda T, Yoshida H, Hori S., Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells., Immunity,47, 268-283.e9, 2017

Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Uraki R, Ito M, Nakajima N, Yamada S, Imai M, Kawakami E, Tomita Y, Fukuyama S, Itoh Y, Ogasawara K, Lopes TJS, Watanabe T, Moncla LH, Hasegawa H, Friedrich TC, Neumann G, Kawaoka Y., Emergence of oseltamivir-resistant H7N9 influenza viruses in immunosuppressed cynomolgus macaques., The Journal of infectious diseases,216, 582-593, 2017    

 

2016 

Kawakami E*, Nakaoka S, Ohta T, Kitano H., Weighted enrichment method for prediction of transcription regulators from transcriptome and global chromatin immunoprecipitation data., Nucleic Acids Res., 44, 5010-21, 2016(*Corresponding author) 

Okada Y, Muramatsu T, Suita N, Kanai M, Kawakami E, Valentina Iotchkova, Nicole Soranzo, Inazawa J, Tanaka T., Significant impact of miRNA–target gene networks on genetics of human complex traits., Scientific reports,6, 22223, 2016

Kawakami E, Singh VK, Matsubara K, Ishii T, Matsuoka Y, Hase T, Kulkarni P, Siddiqui K, Kodilkar J, Danve N, Subramanian I, Katoh M, Shimizu-Yoshida Y, Ghosh S, Jere A, Kitano H., Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways., npj Syst. Biol. App., 2, 15018, 2016

 

2015 

Picazarri K, Nakada-Tsukui K, Tsuboi K, Miyamoto E, Watanabe N, Kawakami E, Nozaki T., Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica., Cell. Microbiol., 17, 1510-22, 2015

Shoemaker JE, Fukuyama S, Eisfeld AJ, Zhao D, Kawakami E, Sakabe S, Maemura T, Gorai T, Katsura H, Muramoto Y, Watanabe S, Watanabe T, Fuji K, Matsuoka Y, Kitano H, Kawaoka Y., An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation., PLoS Pathog.,11, e1004856, 2015

 

2014

Watanabe T, Kawakami E, Shoemaker JE, Lopes TJ, Matsuoka Y, Tomita Y, Kozuka-Hata H, Gorai T, Kuwahara T, Takeda E, Nagata A, Takano R, Kiso M, Yamashita M, Sakai-Tagawa Y, Katsura H, Nonaka N, Fujii H, Fujii K, Sugita Y, Noda T, Goto H, Fukuyama S, Watanabe S, Neumann G, Oyama M, Kitano H, Kawaoka Y., Influenza virus-host interactome screen as a platform for antiviral drug development., Cell Host Microbe, 16, 795-805, 2014

Muramoto Y, Shoemaker JE, Le MQ, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y., Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses., J. Virol., 88, 8981-97, 2014 

 

2013 

Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y, Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y., Characterization of H7N9 influenza A viruses isolated from humans., Nature, 501, 551-5, 2013

Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y., Identification of novel influenza A virus proteins translated from PA mRNA., J. Virol.,87, 2455-62, 2013

 

2012 

Watanabe T, Imai M, Watanabe S, Shinya K, Hatta M, Li C, Neumann G, Ozawa M,Hanson A, Zhong G, Fukuyama S, Kawakami E, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Kilander A, Dudman SG, Suresh M, Hungnes O, Friedrich TC, Kawaoka Y*., Characterization in vitro and in vivo of pandemic (H1N1) 2009 influenza viruses isolated from patients., J. Virol.86, 9361-9368, 2012

Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher EA, Neumann G, Kawaoka Y*., Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets., Nature,486, 420-428, 2012

Noda T, Sugita Y, Aoyama K, Hirase A, Kawakami E, Miyazawa A, Sagara H, Kawaoka Y*., Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus., Nat. Commun., 3, 639, 2012 

 

2011

Watanabe T, Shinya K, Watanabe S, Imai M, Hatta M, Li C, Wolter BF, Neumann G, Hanson A, Ozawa M, Yamada S, Imai H, Sakabe S, Takano R, Iwatsuki-Horimoto K, Kiso M, Ito M, Fukuyama S, Kawakami E, Gorai T, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Nishio W, Maniwa Y, Igarashi T, Makino A, Travanty EA, Wang J, Kilander A, Dudman SG, Suresh M, Mason RJ, Hungnes O, Friedrich TC, Kawaoka Y*., Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques., J. Virol., 85, 13195-13203, 2011

Eisfeld AJ, Kawakami E, Watanabe T, Neumann G, Kawaoka Y*., RAB11A is essential for transport of the influenza virus genome to the plasma membrane., J. Virol., 85, 6117-6126, 2011

Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S,Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y*., Seroprevalence of pandemic 2009 (H1N1) influenza A virus among schoolchildren and their parents in Tokyo, Japan., Clin. Vaccine Immunol., 18, 860-866, 2011

Kawakami E, Watanabe T, Fujii K, Goto H, Watanabe S, Noda T, Kawaoka Y*., Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA., J. Virol. Methods,173, 1-6, 2011

Tamura D, Sugaya N, Ozawa M, Takano R, Ichikawa M, Yamazaki M, Kawakami C, Shimizu H, Uehara R, Kiso M, Kawakami E, Mitamura K, Kawaoka Y*., Frequency of drug-resistant viruses and virus shedding in pediatric influenza patients treated with neuraminidase inhibitors., Clin. Infect. Dis., 52, 432-437, 2011

Akarsu H, Iwatsuki-Horimoto K, Noda T, Kawakami E, Katsura H, Baudin F, Horimoto T, Kawaoka Y., Structure-based design of NS2 mutants for attenuated influenza A virus vaccines., Virus res., 155, 240-248, 2011

 

 
 
 
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