- 2009
- Immunization with oligomannose-coated liposome-entrapped dense granule
protein 7 protects dams and offspring from Neosporacaninum infection in
mice. Nishikawa Y, Zhang H,Ikehara Y, Kojima N, XuanX, YokoyamaN. Clin
Vaccine Immunol. 2009 Jun;16(6):792-7. Epub 2009 Apr 8.
Isolation and pathogenic characterization of an OB1 variant of Babesia
rodhaini which has a glycophorin A independent pathwaytomurine red blood
cells. Takabatake N., Iseki H.,IkeharaY., Kanuka H.,Yokoyama N., Sekimizu
K., Igarashi I. VeterinaryParasitology, 2009 Feb5;159(2):97-104
Strategy for glycoproteomics:Identification of Glyco-Alteration Using Multiple
Glycan Profiling Tool. Ito H, Kuno A, Sawaki H, Sogabe M,Ozaki H, Tanaka
Y, Mizokami M,Shoda JI, Angata T, Sato T, Hirabayashi J,Ikehara Y, Narimatsu
H. J Proteome Res. 2009 Mar;8(3):1358-67.
Human C21orf63 is a heparin-binding protein. Mitsunaga K, Itadani JH,Shikanai
T, Tateno H,Ikehara Y,Hirabayashi J, Narimatsu H, Angata T. J Biochem.
146(3): 369-73,2009 (May 26. e-pub)
Effect of oligomannose-coated liposome-based vaccine on rodent babesiosis.
Ishigame T., Takabatake N., Iseki H., Ota N.,Koyama A., Igarashi I., Nishikawa
Y.,Ikehara Y., Kojima N.,Yokoyama N.,
J Protozoology Research, 19(1):10-23, 2009
Induction of anti-tumor immune responses with oligomannosecoated liposomes
targeting to peritoneal macrophage. Tsujimura K.,Ikehara Y.,Nagata T.,
Koide Y., Kojima N., Procedia in Vaccinology 1 (2009)127-134,
- 2008
- Effect of CD4+CD25+ T cell-depletion on acute lethal infection of mice
with Trypanosoma congolense. Namangala B, YokoyamaN,Ikehara Y,Taguchi O,
Tsujimura K, Sugimoto C, Inoue N. Journal of Veterinary MedicalScience,
Aug;70(8):751-9. 2008
Oligomannose-coated liposomes as a therapeutic antigen-deliveryandan adjuvant
vehicle for induction of in vivo tumor immunity. KojimaN, Biao L, Nakayama
T, Ishii M,Ikehara Y, Tsujimura K. J Control Release. Jul2;129(1):26-32.
2008
Immunocytochemical analysis for intracellular dynamics of C1GalT associated
with molecular chaperone, Cosmc. Narimatsu Y,Ikehara Y,Iwasaki H, Nonomura
C,Sato T, Nakanishi H, Narimatsu H. Biochem Biophys ResCommun. 2008Feb
1;366(1):199-205. Epub 2007 Dec 3.
Effective induction of anti-tumor immune responses with Oligomannose-Coated
Liposome targeting to intraperitoneal phagocyticcells. Ikehara Y, Shiuchi
N, Kabata-Ikehara S,Nakanishi H, Yokoyama N, Takagi H, Nagata T, Koide
Y, Kuzushima K, Takahashi T,Tsujimura K, Kojima N. Cancer Letters, 260(1-2):137-145,
2008Feb
【総説・書籍】
池原 譲 上皮間葉系移行（Epithelial MesenchymalTranstion）の形態学的な検出法がんの浸潤・転移研究ハンドブック.
318-323 2008.胃癌の発症・進展の各段階におけるバイオマーカーについて,発癌および再発予測に関わる糖鎖バイオマーカーを中心に概説した。最初に,胃癌のピロリ菌感染による発癌リスクのバイオマーカーとして,ピロリ菌側のCagAやCagPAIなどの遺伝子型,宿主側のフコース転移酵素やIL1‐βなどの遺伝子多型,をバイオマーカー候補として挙げた。次いで,胃癌の再発予測に関して,腹膜転移,リンパ節転移および血行性転移における微小転移診断のためのバイオマーカーの最近の進歩と治療適応への応用について述べた。CEAを指標とする定量RT‐PCR法による腹腔内遊離癌細胞の検出法や抗体標識による末梢血中遊離癌細胞検出法の有用性について述べた。さらに,胃癌の予後あるいは治療効果判定のバイオマーカーとしてCA72‐4について述べた。
栂谷内晶、小園裕子、佐藤 隆、池原 譲、成松 久.:ポリラクトサミン糖鎖の免疫系での役割 遺伝子医学MOOK 11号「臨床糖鎖バイオマーカーの開発‐糖鎖機能の解明とその応用」210－216
2008
池原 譲、中西 速夫.糖鎖機能を活用した癌腹腔内転移治療技術の開発とその応用,遺伝子医学MOOK 11号「臨床糖鎖バイオマーカーの開発‐糖鎖機能の解明とその応用」 226－233
2008.
成松 由規、池原 譲、佐藤 隆、成松 久.IgA腎症と糖鎖,遺伝子医学MOOK 11号「臨床糖鎖バイオマーカーの開発‐糖鎖機能の解明とその応用」259－263
2008
中西 速夫、池原 譲.胃癌のバイオマーカー遺伝子医学MOOK11号「臨床糖鎖バイオマーカーの開発‐糖鎖機能の解明とその応用」278－284 2008.
池原 譲、中西 速夫.糖鎖機能を活用した癌腹腔内転移治療技術の開発とその応用,遺伝子医学MOOK11号「臨床糖鎖バイオマーカーの開発‐糖鎖機能の解明とその応用」 226－233
2008.
栂谷内 晶、小園 裕子、佐藤 隆、久野 敦、平林 淳、池原 譲、成松 久ポリラクトサミン糖鎖による細胞機能調節 蛋白質核酸酵素9月増刊号「糖鎖情報の独自性と普遍性」53(12)
:1590-1597, 2008.
Kuboki, M., Yamaguchi, T., Yamanaka, M., Mizuno, D., Takagi, H., Abe,Y.,
Ota, N., Kobayashi, Y., Kida, K., Kojima, N., Ikehara, Y., and Yokoyama,
N. Adjuvant effect of oligomannose-coated liposome incattle. Jpn. J. Vet.
Parasitol.(7) 78.2008.
Takabatake, N., Iseki, H., Ikehara, Y., Sekimizu, K., Yokoyama, N., and
Igarashi, I. Isolation of a variant of Babesia rodhaini, which can grow
up inglycophorin A-knockout mice. Jpn. J. Vet. Parasitol.(6)128.200
- 2007
- Effective induction of anti-tumor immune responses with Oligomannose-Coated
Liposome targeting to intraperitoneal phagocyticcells.Ikehara Y., Shiuchi
N.,Kabata-Ikehara S.,Nakanishi H., YokoyamaN., Takagi H., Nagata T., Koide
Y., Kuzushima K.,Takahashi T., Tsujimura K. andKojima N.Cancer Lett. 2007
Dec 10
Immunocytochemical analysis for intracellular dynamics of C1GalT associated
with molecular chaperone, Cosmc. Narimatsu Y, Ikehara Y, Iwasaki H, Nonomura
C, Sato T, Nakanishi H, Narimatsu H. Biochem Biophys Res Commun. 2008 Feb
1;366(1):199-205. Epub 2007 Dec 3.
Asexual growth of babesia bovis is inhibited by specific sulfated glycoconjugates.
Bork S., Yokoyama N., Hashiba S., NakamuraK., Takabatake N., OkamuraM.,Ikehara
Y., and Igarashi I.Journal of ParasitologyDec;93(6):1501-4 2007
Solitary bone metastasis as the first clinical manifestation in a patient
with small bowel adenocarcinoma. Yamada K,Ikehara Y., Nakanishi H, Kozawa
E, Tatematsu M,SugiuraH. J OrthopSci. 2007 Nov;12(6):606-10. Epub 2007
Nov 30. Noabstract available.
Polylactosamine on glycoproteins influences basal levels of lymphocyte
and macrophage activation. Togayachi A, Kozono Y, Ishida H, Abe S,Suzuki
N, Tsunoda Y,Hagiwara K, Kuno A, Ohkura T, Sato N, Sato T, HirabayashiJ,Ikehara
Y,Tachibana K, Narimatsu H. Proc Natl Acad Sci US A. 2007 Oct 2;104(40):15829-34.
Epub 2007Sep 21.
Involvement of A Host Erythrocyte Sialic Acid Content In Babesia Bovis
Infection. Takabatake N., Okamura M., Yokoyama N., Okubo K.,IkeharaY.,Igarashi
I. J VetMed Sci. 2007 Oct;69(10):999-1004.
Glycophorin A-knockout mice, which lost sialoglycoproteins from the red
blood cell membrane,are resistant to lethal infection ofBabesia rodhaini.
Takabatake N, Okamura M,Yokoyama N,Ikehara Y, Akimitsu N,Arimitsu N, Hamamoto
H, Sekimizu K,Suzuki H, Igarashi I. Vet Parasitol. 2007 Sep 1;148(2):93-101.Epub
2007 Jul 24.
Preliminary evaluation of oligomannose-coated liposome vaccines against
lethal protozoan infections in mice. Kuboki N., Tiwananthagorn W., Takagi
H., Nakayama T.,Xuenan X.,Inoue N., Igarashi I., Tsujimura K.,IkeharaY.,
Kojima N., and YokoyamaN. Journal of Protozoology Research, 17, 9-15,2007
Modification of host erythrocyte membranes by trypsin and chymotrypsin
treatments and effects on the in vitro growth of bovineand equine babesia
parasites. Okamura M., Yokoyama N., Takabatake N., Okubo K.,Ikehara Y.,Igarashi
I. J Parasitol. 2007Feb;93(1):208-11.
Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance
of Lewis x structure in brain and increased anxiety-like behaviors. Kudo
T, Fujii T, Ikegami S, InokuchiK, Takayama Y,Ikehara Y,Nishihara S, Togayachi
A, Takahashi S,Tachibana K,, Yuasa S, Narimatsu H. Glycobiology. 2007 Jan;17(1):1-9.Epub
2006 Sep 14. Erratum in: Glycobiology. 2007 Oct;17(10):1030.
Babesia bovis:Subcellular localization of host erythrocyte membrane components
during their asexual growth. Okamura M, Yokoyama N, Takabatake N, Okubo
K,Ikehara Y, Igarashi I. Exp Parasitol.2007 Jan 3;116(1):91-4. Epub 2007
Jan 4
【総説・書籍】
Ikehara Y.and Kojima N. The development of noveloligomannose-coated liposome-basedanticancer
drug delivery systemtointraperitoneal cancer. Current opinion of Mol.Ther.9:53-61,2007.
Nakanishi H, Kodera Y,Ikehara Y. HER signaling asmultiple therapeutictargets
in gastric cancers (invited review article) Protein Database,In press,2007.
Nakanishi H, Ito S, Mochizuki Y, Ohashi N, IkeharaY,Yamamura Y,Kodera
Y. Peritoneal carcinomatosis; A newdiagnostic and therapeuticstrategy.
In Research Focus on GastricCancer. Edited by Cardinni DC., NovaScientific
Publishers. In press, 2007.
Nakanishi H., HaraH., Ikehara Y., Tatematsu M. Non-invasive and real-timemonitoring
of molecular targeting therapy for lymph node and peritonealmetastasis
in nude mice bearing xenografts of human colorectal cancer cellstagged
with GFP and DsRed. Proceeding of SPIE, 6449; 644910.1-9, 2007
Yokoyama, N.,Namangala, B., Inoue, N., Igarashi, I., Sugimoto, C., Ikehara,
Y.,Taguchi, O., and Tsujimura, K. Effect of Treg cell-depletion oninfection
of Babesia and Trypanosoma parasites in the mice. Jpn. J.Vet. Parasitol.(5)59,2007.
- 2006
- A polymorphism of C-to-T substitution at-31 IL1B is associated with the
risk of advanced gastric adenocarcinoma in aJapanesepopulation. Ikehara
SK,Ikehara Y, Matsuo K, Hirose K, Niwa T,Ito H,Ito S, Kodera Y, Yamamura
Y, Nakanishi H, Tatematsu M, Tajima K. J Hum Genet.2006;51(11):927-33.
Epub 2006 Sep 28.
A Carbohydrate Recognition-Based Drug Delivery and Controlled Release System
using Intraperitoneal Macrophages as aCellular Vehicle. Ikehara Y, Niwa
T, Biao L, Ikehara SK, Ohashi N,Kobayashi T,Shimizu Y, Kojima N, Nakanishi
H. Cancer Res. 2006 Sep1;66(17):8740-8.
Apical Golgi localization of N,N'-diacetyllactosediamine synthase, {beta}4GalNAc-T3,
is responsible for LacdiNAc expression ongastric mucosa. Ikehara Y, SatoT,
Niwa T, Nakamura S, Gotoh M,Ikehara SK, Kiyohara K, Aoki C, Iwai T,Nakanishi
H, Hirabayashi J, Tatematsu M,Narimatsu H. Glycobiology. 2006 Sep;16(9):777-85.
Epub 2006 May 25. ]
Biological significance of isolated tumor cells and micrometastasis in
lymph nodes evaluated using a green fluorescent protein-tagged human gastric
cancer cellline. Yokoyama H,Nakanishi H, Kodera Y,Ikehara Y, OhashiN, Ito
Y, Koike M, Fujiwara M,Tatematsu M, Nakao A. Clin Cancer Res. 2006 Jan15;12(2):361-8.]
Molecular basis for sensitivity and acquired resistance to gefitinib in
HER2-overexpressing human gastric cancer cell lines derivedfrom liver metastasis.
Yokoyama H,Ikehara Y, Kodera Y,Ikehara S, YatabeY,Mochizuki Y, Koike M,
Fujiwara M, Nakao A, Tatematsu M, Nakanishi H. Br J Cancer. 2006 Dec4;95(11):1504-13.
Modification of host erythrocyte membranes by trypsin and chymotrypsin
treatments and effects on the in vitro growth of bovineand equine babesia
parasites. Okamura M., Yokoyama N., TakabatakeN., Okubo K.,Ikehara Y.,
Igarashi I.
Journal of Parasitology 2007 /2006 In press
- 2005
- Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments
with delayed protein transport. Sohda M, Misumi Y, Yoshimura S, Nakamura
N, Fusano T, Sakisaka S, Ogata S, Fujimoto J, Kiyokawa N, Ikehara Y.Biochem
Biophys Res Commun. 2005 Dec 16;338(2):1268-74. Epub 2005 Oct 24。PMID:
16256943 [PubMed - indexed for MEDLINE]
Establishment and characterization of a human colonic mucinous carcinoma
cell line with predominant goblet-cell differentiationfrom liver metastasis.
Yamachika T, Nakanishi H, Yasui K,Ikehara Y, Niwa T, Wanibuchi H, Tatematsu
M, Fukushima S. Pathol Int. 2005 Sep;55(9):550-7.PMID: 16143030 [PubMed
- indexed for MEDLINE]
Establishment and characterization of three novel human gastric cancer
cell lines with differentiated intestinal phenotype derivedfrom liver metastasis.
Nakanishi H, Yasui K, Ikehara Y, Yokoyama H, Munesue S, Kodera Y, Tatematsu
M. Clin Exp Metastasis. 2005;22(2):137-47.PMID: 16086234 [PubMed - indexed
for MEDLINE]
Babesia caballi and Babesia equi: implications of host sialic acids in
erythrocyte infection. Okamura M, Yokoyama N, Wickramathilaka NP, Takabatake
N, Ikehara Y, Igarashi I. Exp Parasitol. 2005 Aug;110(4):406-11.PMID: 15869756
[PubMed - indexed for MEDLINE]
Helicobacter pylori-dependent NF-kappa B activation in newly established
Mongolian gerbil gastric cancer cell lines. Nozaki K, Tanaka H, Ikehara
Y, Cao X, Nakanishi H, Azuma T, Yamazaki S, Yamaoka Y, Shimizu N, Mafune
K, Kaminishi M, Tatematsu M. Cancer Sci. 2005 Mar;96(3):170-5.PMID: 15771620
[PubMed - indexed for MEDLINE]
Mixed gastric- and intestinal-type metaplasia is formed by cells with dual
intestinal and gastric differentiation. Niwa T,Ikehara Y, Nakanishi H,
Tanaka H, Inada K, Tsukamoto T, Ichinose M, Tatematsu M. J Histochem Cytochem.
2005 Jan;53(1):75-85. PMID: 15637340 [PubMed - indexed for MEDLINE
Transfection of antisense core 2beta1,6-N-acetylglucosaminyltransferase-1
cDNA suppressesselectin ligand expression and tissueinfiltration of B-cell
precursor leukemia cells. Kikuchi J,Ozaki H,Nonomura C, Shinohara H, IguchiS,
Nojiri H,Hamada H, Kiuchi A, Nakamura M. Leukemia. 2005 Nov;19(11):1934-40.PMID:16179912
[PubMed - indexed for MEDLINE]
【総説・書籍】
野崎 浩二、池原 譲、田中 晴就、中西 速夫、真船 健一、上西 紀夫、立松 正衛： スナネズミ胃癌細胞株の樹立とHP感染が及ぼす影響の解析
日本ヘリコバクター学会誌Vol 6 No2P34-38, 2005
横山 直明、岡村 雅史、池原 譲、Sabine Bork、杉本 千尋、五十嵐 郁男.Babesiabovis増殖阻害活性を示すPeptide
display phage群のスクリーニング.獣医寄生虫学会誌 3(2):20、2005.
- 2004
- Negative regulation of T cell receptor signaling bySiglec-7(p70/AIRM) and
Siglec-9. Ikehara Y,Ikehaa SK, PaulsonJC. J Biol Chem. 2004 Oct8;279(41):43117-25.
Epub2004 Aug 3. PMID: 15292262 [PubMed - indexed forMEDLINE]
Lewis and Secretor status and Helicobacter pylorieradication, Matsuo K.,Ikehara
Y., Nakamura T.,Hamajima N. Epidemiol. Infect.(2004), 132, 997-1000.2004
Growth inhibitory effect of heparin on Babesiaparasites. Sabine Bork, Yokoyama
N.,Ikehara Y., KumarS., Sugimoto C., and Igarashi I. Antimicrob Agents
Chemother. 2004 Jan;48(1):236-41. PMID: 14693545 [PubMed - indexed for
MEDLINE] .
- 2003
- Lewis type 1 antigen synthase (beta3Gal-T5) istranscriptionally regulated
by homeoproteins. Isshiki S, Kudo T, Nishihara S,Ikehara Y, TogayachiA,
Furuya A, Shitara K, Kubota T, Watanabe M,Kitajima M, NarimatsuH. JBiol
Chem. 2003 Sep 19;278(38):36611-20.Epub 2003 Jul 10. PMID: 12855703[PubMed
- indexed for MEDLINE]
Effectof early eradication on Helicobacter pylori-related gastric carcinogenesis
in Mongolian gerbils. Nozaki K, Shimizu N,Ikehara Y,Inoue M, TsukamotoT,
Inada K, Tanaka H, Kumagai T, Kaminishi M, Tatematsu M. Cancer Sci. 2003
Mar;94(3):235-9. PMID: 12824915 [PubMed - indexed forMEDLINE]
ABO blood type,Lewis and Secretor genotypes, and chronic atrophic gastritis:
across- sectionalstudy in Japan. Shibata A, Hamajima N,Ikehara Y, Saito
T, Matsuo K,Katsuda N, Tajima K, Tatematsu M, TominagaS. Gastric Cancer.
2003;6(1):8-16.PMID: 12673421 [PubMed - indexedfor MEDLINE]
Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expressionin brain.
Nishihara S, Iwasaki H, Nakajima K, TogayachiA,Ikehara Y,Kudo T, Kushi
Y, Furuya A, Shitara K, NarimatsuH. Glycobiology. 2003Jun;13(6):445-55.
Epub 2003 Feb 20. PMID: 12626397[PubMed - indexed forMEDLINE]
Smoking and polymorphisms offucosyltransferase gene Leaffect success of
H. pylori eradication with lansoprazole, amoxicillin, andclarithromycin.
Matsuo K, Hamajima N,Ikehara Y, SuzukiT, NakamuraT, Matsuura A, Tajima
K, Tominaga S. Epidemiol Infect.2003 Apr;130(2):227-33. PMID: 12729191
[PubMed -indexed for MEDLINE]
- 2002
- Lack of consistency in the associations of Helicobacterpylori seropositivity
with Se and Lepolymorphisms among Japanese. Hamajima N, Shibata A,Ikehara
Y, Katsuda N, Mori S,Ito H,Matsuo K, Tajima K, Tominaga S. Gastric Cancer.2002;5(4):194-200.PMID:
12491076 [PubMed - indexed for MEDLINE]
Reversibility ofheterotopic proliferative glands in glandular stomach of
Helicobacter pylori-infected Mongolian gerbils on eradication. Nozaki K,
Shimizu N, Tsukamoto T, Inada K, Cao X,Ikehara Y, Kaminishi M, Sugiyama
A, Tatematsu M. Jpn J Cancer Res. 2002 Apr;93(4):374-81. PMID: 11985786
[PubMed -indexed forMEDLINE]
- 2001
- Identification of Paneth cells in pyloric glands associated with gastric
and intestinal mixed-type intestinal metaplasia of the humanstomach. Inada
K, Tanaka H, Nakanishi H, Tsukamoto T, Ikehara Y, Tatematsu K, Nakamura
S, Porter EM, Tatematsu M.Virchows Arch. 2001 Jul;439(1):14-20
Real-time observation of micrometastasis formation in the living mouse
liver using a green fluorescent protein gene-tagged rattongue carcinoma
cell line.Ito S.,Nakanishi H.,Ikehara Y., Kato T., Akiyama S., Nakao A.,
Tatematsu M.:
J. of Cancer, 93(2):212-217, 2001.
Polymorphisms of Two Fucosyltransferase Genes (Lewis and Secretor Genes)
Involving Type I Lewis Antigens Are Associated withthe Presence of Anti-Helicobacter
Pylori IgG Antibody. Ikehara Y., Nishiahra S., Yasutomi H.,Kitamura T.,
Matsuo K., Shimizu N., Inada KI., Kodera Y., Yamamura Y.,Narimatsu H.,
Hamajima N., and Tatematsu M.: Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):971-7.
- 2000
- Eradication diminishes enhancing effects of Helicobacter pyloriinfection
on Glandular stomach carcinogenesis in Mongolian gerbils. Shimizu N.,Ikehara
Y., Inada KI., Nakanishi H., Tsukamoto T.,Yoshikawa A., Nozaki K., Kaminishi
M., Kuramoto S., Sugiyama A., Katsuyama T.,Tatematsu M.:Cancer Res., 60:1512-1514,
2000.
Molecular Cloning and GenomicAnalysis of Mouse GalNAc alpha 2,6-Sialyltransferase
ST6GalNAc I).Kurosawa N., Takashima S., Kono M.,Ikehara Y., Inoue M.,Tachida
Y., Narimatsu H., Tsuji S.: J. Biochem.(Tokyo),127:845-854, 2000.