研究業績

  1. Nakahashi-Ouchida R., Fujihashi K., Kurashima Y., Yuki Y., Kiyono H.「Nasal vaccines: solutions for respiratory infectious diseases.」『Trends Mol Med.』2022: S1471-4914(22)00274-X. doi: 10.1016/j.molmed.2022.10.009.
  2. Zhang Z., Ernst P.B., Kiyono H., Kurashima Y.「Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.」『Front Immunol.』2022:13:937120. doi: 10.3389/fimmu.2022.937120. (Corresponding author)
  3. Zhang Z., Tanaka I., Pan Z., Ernst P.B., Kiyono H., Kurashima Y.「Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas-intestinal barrier axis.」『Eur J Immunol. 』2022: 52(7):1035-1046. doi: 10.1002/eji.202149532. (Corresponding author)
  4. Zhang Z., and Kurashima Y.「Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation」『Cells』10(7):1615, 2021. doi: 10.3390/cells10071615. (Corresponding author)
  5. Sato S., Kainuma K., Noda T., Ebisawa M., Futamura M., Imamura T., Miyagawa A., Nakajima S., Ogawa Y., Inomata T., Kan-O K., Kurashima Y, Masaki K., Myojin T., Nishioka Y., Sakashita M, Tamari M., Morita H., Adachi T.「Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan. 」『Allergol. Int.』 2022 Mar 20;S1323-8930(22)00009-0. doi: 10.1016/j.alit.2022.02.002.
  6. Adachi T., Ogawa Y., Fukushi T., Ito K., Koizumi A., Shirabe M., Toriya M, Hirako J., Inomata T, Masaki K, Sasano R, Sato S, Kainuma K, Futamura M, Kan-O K., Kurashima Y, Nakajima S., Sakashita M., Morita H., Iwamoto A., Nishima S., Tamari M, Iizuka H.「Research impact analysis of international funding agencies in the realm of allergy and immunology」『Allergy』2022 in press doi: 10.1111/all.15249.
  7. Kamioka M., Goto Y., Nakamura K., Yokoi Y., Sugimoto R., Ohira S., Kurashima Y, Umemoto S., Sato S., Kunisawa J., Takahashi Y., Domino S.E., Renauld J.C., Nakae S., Iwakura Y., Ernst P.B., Ayabe T., Kiyono H.「Intestinal commensal microbiota and cytokines regulate Fut2 + Paneth cells for gut defense」『Proc Natl Acad Sci USA』119(3) e2115230119, 2022.
  8. Zhang Z., and Kurashima Y.「Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation」『Cells』10(7):1615, 2021. doi: 10.3390/cells10071615. (Corresponding author)
  9. Kurashima Y., Kigoshi T., Murasaki S., Arai F., Shimada K., Seki N., Kim Y.G., Hase K., Ohno H., Kawano K., Ashida H., Suzuki T, Morimoto M., Saito Y., Sasou A., Goda Y., Yuki Y., Inagaki Y., Iijima H., Suda W., Hattori M., Kiyono H.「Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation」『Nat. Commun.』12(1) 1067 - 1067. 2021. (Corresponding author)
  10. Takasato Y., Kurashima Y., Kiuchi M., Hirahara K., Murasaki S., Arai F., Izawa K., Kaitani A., Shimada K., Saito Y., Toyoshima S., Nakamura M., Fujisawa K., Okayama Y., Kunisawa J., Kubo M., Takemura N., Uematsu S., Akira S., Kitaura J., Takahashi T., Nakayama T., Kiyono H.「Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy」『Mucosa. Immunol.』doi: 10.1038/s41385-020-00358-3. 2020. (Corresponding author)
  11. Matsumura S., Kurashima Y., Murasaki S., Morimoto M., Arai F., Saito Y., Katayama N., Kim D., Inagaki Y., Kudo T., Ernst P., Shimizu T., Kiyono H.「Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation」『Sci. Rep.』2020 10(1):18351. doi: 10.1038/s41598-020-75186-3. 2020. (Corresponding author)
  12. Takahashi I., Hosomi K., Nagatake T., Tobou H., Yamamoto D., Hayashi I., Kurashima Y., Sato S., Shibata N., Goto Y., Maruyama F., Nakagawa I., Kuwae A., Abe A., Kunisawa J., Kiyono H.「Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia」『Int. Immunol.』doi: 10.1093/intimm/dxz071. 2019
  13. Joo S., Suwanto A., Sato A., Nakahashi-Ouchida R., Mori H. Uchida Y., Sato S., Kurashima Y.,Yuki Y., Fujihashi K., Kawaguchi Y., Kiyono H. 「A role for the CCR5–CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization」『Mucosal Immunol.』12(6):1391-1403. doi: 10.1038/s41385-019-0203-z. 2019.
  14. Nishida K., Hasegawa A., Yamasaki S., Uchida R., Ohashi W.,Kurashima Y.,Kunisawa J., Kimura S., Iwanaga T., Watarai H., Hase S., Ogura H., Nakayama M., Kashiwakura J., Okayama Y., Kubo M., Ohara O., Kiyono H., Koseki H., Murakami M., Hirano T. 「Mast cells play role in wound healing through the ZnT2 / GPR39 / IL-6 axis.」『Sci. Rep.』25;9(1):10842. doi: 10.1038/s41598-019-47132-5. 2019.
  15. Kurashima Y.,Tokuhara D., Kamioka M., Inagaki Y., Kiyono H.「Intrinsic control of surface immune and epithelial homeostasis by tissue-resident gut stromal cells」『Front. Immunol.』19; 10:1281. doi: 10.3389/fimmu.2019.01281., 2019. (Corresponding author)
  16. Hashizume-Takizawa T., Shibata N., Kurashima Y.,Kiyono H., Kurita-Ochiai T., Fujihashi K.「Distinct roles for Peyer’s Patch B Cells for induction of antigen-specific IgA antibody responses in mice administered pral recombinant Salmonella」『Int. Immunol.』doi: 10.1093/intimm/dxz029., 2019.
  17. Tokuhara D., Kurashima Y., Kamioka M., Nakayama T., Ernst P., Kiyono H.「A comprehensive understanding of the gut mucosal immune system in allergic inflammation」『Allergol. Int.』68(1):17-25. doi: 10.1016/j.alit.2018.09.004., 2019.
  18. Inami A., Kiyono H., Kurashima Y.「ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract」『Int. J. Mol. Sci.』19(8). pii: E2371. doi: 10.3390/ijms19082371, 2018. (Corresponding author)
  19. Takemura N., Kurashima Y., Mori Y., Okada K., Ogino T., Osawa H., Matsuno H., Aayam L., Kaneto S., Park EJ., Sato S., Matsunaga K., Tamura Y., Ouchi Y., Kumagai Y., Kobayashi D., Suzuki Y., Yoshioka Y., Nishimura J., Mori M., Ishii KJ., Rothenberg ME., Kiyono H., Akira S., Uematsu S.「Eosinophil depletion suppresses radiation-induced small intestinal fibrosis」『Sci .Transl. Med.』10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333, 2018.
  20. Takahashi Y., Sato S., Kurashima Y., Yamamoto T., Kurokawa S., Yuki Y., Takemura N., Uematsu S., Lai CY., Otsu M., Matsuno H., Osawa H., Mizushima T., Nishimura J., Hayashi M., Yamaguchi T., Kiyono H.「A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids」『Stem Cell Reports』10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004, 2018.
  21. Takahashi Y., Sato S., Kurashima Y.,Lai CY., Otsu M., Hayashi M.,Yamagushi T., Kiyono H.,「Reciprocal inflammatory Signaling between intestinal epithelial cells and adipocytes in the absence of immune cells」『EBioMedicine』23: 34-45 doi:10.1016/j.ebiom.2017.07.027.2017.
  22. Kurashima Y.,Yamamoto D., Nelson S., Uematsu S., Ernst PB., Nakayama T., Kiyono H.「Mucosal mesenchymal cells: Secondary barrier and peripheral educator for the gut immune system」『Front. Immunol.』8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017.
  23. Shimokawa C., Kanaya T., Hachisuka M., Ishiwata K., Hisaeda H., Kurashima Y., Kiyono H., Yoshimoto T., Kaisho T., Ohno H.「Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of Helminth infections」『Immunity』46(5):863-874, 2017.
  24. Toyoshima S., Wakamatsu E., Ishida, Y. Obata Y., Kurashima Y., Kiyono H., and Abe R.「The spleen is the site where mast cells are induced in the development of food allergy」『Int. Immunol.』29(1):31-45, 2017
  25. Furuta Y., Tsai S.H., Kinoshita M., Fujimoto K., Okumura R., Umemoto E., Kurashima Y. Kiyono H., Kayama H., and Takeda K. 「E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine」『PLoS ONE』12(2):e0172509, 2017.
  26. Kurashima Y., and Kiyono H., 「Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing」『Annual Review Immunology』35:119-147, 2017
  27. Joo S., Fukuyama Y., Park EJ., Yuki Y., Kurashima Y., Ouchida R., Ziegler SF., and Kiyono H.「Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response」『Mucosal Immunol.』10(4):901-911, 2017.
  28. Nelson S., Kiyono H., and Kurashima Y. 「Epithelial extracellular ATP: an initiator of immunity to parasitic infections」『Immunology and Cell Biology』95(2):117-118, 2016.
  29. Wakita D., Kurashima Y., Crother T., Rivas M.N., Lee Y., Chen S., Fury W., Bai Y., Wagner S., Li D., Lehman T., Fishbein M., Hoffman H., Shah P., Shimada K., and Arditi M. 「The Role of IL-1 signaling in a mouse model of Kawasaki Disease-associated Abdominal Aortic Aneurysm」『Arteriosclerosis, Thrombosis, and Vascular Biology』36(5):886-97. doi: 10.1161/ATVBAHA.115.307072, 2016.
  30. Goto Y, Kurashima Y., and Kiyono H. 「The gut microbiota and inflammatory bowel disease」『Curr. Opin. Rheumatol.』 (4):388-96. doi: 10.1097/BOR.0000000000000192, 2015
  31. Kunisawa J., Arita M., Hayasaka T., Harada T, Iwamoto R., Nagasawa R., Shikata S., Nagatake T., Suzuki H., Hashimoto E., Kurashima Y., Suzuki Y., Arai H., Setou M., and Kiyono H.「Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut」『Scientific Report』5:9750. doi: 10.1038/srep09750, 2015.
  32. Kurashima Y., Kiyono H., and Kunisawa J. 「Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation」『Mediators of Inflammation』427125. doi: 10.1155/2015/427125, 2015.
  33. Tsai S.H., Kinoshita M., Kusu T., Kayama H., Okumura R., Ikeda K., Shimada Y., Takeda A., Yoshikawa S., Obata-Ninomiya K., Kurashima Y., Sato S., Umemoto E., Kiyono H., Karasuyama H., and Takeda K. 「The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells」『Immunity』42(2):279-293, 2015.
  34. Kishida K., Kohyama M., Kurashima Y., Kogure Y., Wang J., Hirayasu K., Suenaga T., Kiyono H., Kunisawa J., and Arase H.　 「Negative regulation of DSS-induced experimental colitis by PILRα」『Int. Immunol.』6, 307-314, 2015.
  35. Nakajima-Adachi H., Kikuchi A., Fujimura Y., Shibahara K., Makino T., Goseki-Sone M., Kihara-Fujioka M., Nochi T., Kurashima Y., Igarashi O., Yamamoto M., Kunisawa J., Toda M., Kaminogawa S., Sato R., Kiyono H., and Hachimura S. 「Peyer’s patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy」『PLoS ONE』9(10): e107492, 2014.
  36. Kurashima Y., Amiya T., Fujisawa K., Shibata N., Suzuki Y., Kogure y., Hashimoto E., Otsuka A., Kabashima K., Sato S., Sato T., Kubo M., Akira S., Miyake K., Kunisawa J., and Kiyono H.「Skin-barrier homeostasis through Cyp26b1-mediated inhibition of ATP-dependent mast-cell activation by fibroblasts」『Immunity』40(4):530-541, 2014.
  37. Kurashima Y., and Kiyono H. 「New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development」『Exp. Mol. Med.』46:e83.doi: 10.1038/emm, 2014
  38. Kurashima Y., Goto Y., and Kiyono H.「Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation」『Eur. J. Immunol.』43 (12):3108-15, 2013.
  39. Kunisawa J., Gohda M., Hashimoto E., Ishikawa I., Higuchi M., Suzuki Y., Goto Y., Panea C., Ivanov I.I., Sumiya R., Aayam L., Wake T., Tajiri S., Kurashima Y., Shikata S., Akira S., Takeda K., and Kiyono H. 「Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice」『Nat. Commun.』4:1772. doi: 10.1038/ncomms2718, 2013.
  40. Kurashima Y., Amiya T., Nochi T., Fujisawa K., Haraguchi T., Iba H., Tsutsui H., Sato S., Nakajima S., Iijima H., Kubo M., Kunisawa J., Kiyono H.「 Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors」『Nat. Commun.』 3:1034. doi: 10.1038/ncomms2023, 2012
  41. Tanaka S., Saito Y., Kunisawa J., Kurashima Y., Wake T., Suzuki N., Shultz L.D., Kiyono H., Ishikawa F.「Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice」『J. Immunol.』188 :6145-6155, 2011.
  42. Kunisawa J., Kurashima Y., and Kiyono H.「Gut-associated lymphoid tissues for the development of oral vaccines」『Adv. Drug Deliv. Rev.』64:523-530, 2011.
  43. Gohda M., Kunisawa J., Miura F., Kagiyama Y., Kurashima Y., Higuchi M., Ishikawa I., Ogahara I., and Kiyono H.「Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses」『J. Immunol.』180: 8, 5335-5343, 2008
  44. Kunisawa J., Gohda M., Kurashima Y., Ishikawa I., Higuchi M., and Kiyono H.「Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells」『Blood』111: 9, 4646-4652, 2008.
  45. Kurashima Y., Kunisawa J., Higuchi M., Gohda M., Ishikawa I., Shimizu M., Takayama N., and Kiyono H.「Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy」『J. Immunol.』179: 1577–1585, 2007.
  46. Kunisawa J., Kurashima Y., Gohda M., Higuchi M., Ishikawa I., Miura F., Ogahara I., and Kiyono H.「Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production」『Blood』109: 3749-3756, 2007.
  47. Kunisawa J., Kurashima Y., Higuchi M., Gohda M., Ishikawa I., Ogahara I, Kim N.J., Shimizu M., and Kiyono H.「Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium」『J. Exp. Med.』204: 10, 2335-2348, 2007.

和文総説

  1. 香取明都、藩秦、齊藤ゆかり、倉島洋介.「粘膜間葉系細胞による 修復と炎症遷延化」『臨床免疫・アレルギー科』 Vol. 76 No.2, p. 130-138, 2021
  2. 高里良宏、清野宏、倉島洋介.「アレルギーの分子細胞機構・経口免疫療法によるマスト細胞機能制御」『臨床免疫・アレルギー科』 Vol. 72 No.2, p. 129-135, 2019
  3. 名切真里奈、清野宏、倉島洋介.「腸管粘膜免疫・保護の中軸を担う粘膜間葉系細胞」『リンパ学』Vol. 41 No.2, p. 96-101, 2018
  4. 倉島洋介.「共生と排除を司る粘膜マスト細胞」、『腸内細菌学雑誌』Vol. 132 No.4, p. 159-166, 2018
  5. 山本智久、倉島洋介、清野宏.『腎臓内科・泌尿器科』「in vitro腸管マルチエコシステム解析から見えてきた腸内細菌－上皮－免疫クロストークの多様性」Vol. 7 No.6, p. 613-, 2018
  6. 倉島洋介、山本大樹、清野宏.『実験医学』「粘膜間葉系細胞による腸管恒常性維持」増刊 Vol.35 No.7, 2017
  7. 小暮優太、山本大樹、清野宏、倉島洋介.「組織特異的マスト細胞鎮静化機構の解明と応用」『アレルギーの臨床』3月号, 2016
  8. 小暮優太、倉島洋介、清野宏.「マスト細胞活性化制御による生体バリアの恒常性維持機構」『アレルギー』、一般社団法人日本アレルギー学会、Vol. 65 No. 2 p. 104-112, 2016
  9. 小暮優太、松村成一、倉島洋介、清野宏.「血管・リンパ管系を中心としたマスト細胞の感染制御及び炎症機構」『リンパ学』、日本リンパ学会, Vol. 39 No.2 p. 109-118, 2016
  10. Goto Y, Kurashima Y, and Kiyono H.「Roles of the gut mucosal immune system in symbiosis and immunity」『Jap. J. Clin. Hematol. (RINSHO-KETSUEKI)』、Japanese Society of Hematology, 56(10):345-352, 2015
  11. 倉島洋介、清野宏.「マスト細胞による炎症の誘導と制御」、『炎症と免疫』先端医学社、Vol. 24(1): p 3-9., 2015
  12. 倉島洋介、清野宏.「マスト細胞のP2X7受容体シグナル制御と炎症性腸疾患」『臨床免疫・アレルギー科』、科学評論社、Vol. 64(5), 447-453, 2015
  13. 高里良宏、倉島洋介、清野宏.「炎症性腸疾患および大腸がんにおけるマスト細胞のはたらき」『臨床免疫・アレルギー科』、科学評論社、Vol. 64(5), p435-441, 2015
  14. 倉島洋介、小暮優太、福井渉、清野宏.「マスト細胞鎭靜化と組織恒常性維持」『臨床免疫・アレルギー科』、科学評論社、Vol. 63(6),p551-557, 2015
  15. 倉島洋介、高里良宏、小沼義直、清野宏.「消化器疾患・感染防御におけるマスト細胞」『医学のあゆみ』、医歯薬出版株式会社、253(5): p397-402, 2015
  16. 佐藤健、倉島洋介、國澤純、清野宏.「レチノイン酸代謝による皮膚バリアの恒常性維持 ～線維芽細胞によるマスト細胞調節機構～」『臨床免疫・アレルギー科』、科学評論社、Vol. 63, ( 2), p139-150, 2015　
  17. 倉島洋介、佐藤健、清野宏.「マスト細胞の組織特異性の獲得と炎症」『感染・炎症・免疫』医薬の門社、Vol.45. 1.　p10-19, 2015
  18. 高里良宏、倉島洋介、清野宏、國澤純.「抑制型免疫システムを応用した次世代型抗アレルギーワクチンの開発」『Bioindustry』　シーエムシー出版、6, p55-60, 2014
  19. 倉島洋介、清野宏、國澤純.「細胞外核酸を介したマスト細胞の活性化と炎症性腸疾患」『生化学』、Vol. 86, (6) , p798-802, 2014
  20. 倉島洋介、佐藤健、清野宏、國澤純.「DAMPsによるマスト細胞の活性化と疾患」『臨床免疫・アレルギー科』、科学評論社、Vol. 62, (6) , p675-679, 2014　
  21. 倉島洋介、國澤　純、清野　宏.「マスト細胞活性化因子と炎症性腸疾患」『臨床免疫・アレルギー科』、科学評論社、Vol. 60, (2)、p218-227, 2013
  22. 倉島洋介、國澤　純、清野　宏.「粘膜マスト細胞と疾患」『最新医学』 3月増刊号、最新医学社、Vol. 68, p 704 -718, 2013
  23. 倉島洋介、網谷岳朗、國澤純、清野宏.「食物アレルギーの予防および治療的戦略の確立に向けた粘膜免疫研究の展開」『アレルギー・免疫』　3月号,Vol.18, (3) ,p366-377、2011
  24. 倉島洋介、國澤　純、清野　宏.「粘膜免疫を介したアレルギー克服戦略」『アレルギー』57-2号 (社)日本アレルギー学会　p87-94 、2008
  25. 倉島洋介、國澤　純、清野　宏.「腸内感染防御システムとしての粘膜免疫」『最新医学』3月増刊号、最新医学社p115-123、2005

著書

  1. Yosuke Kurashima 、Hiroshi Kiyono『Chronic Inflammation: Mechanisms and Regulation [Commensal Mutualism: Dysbiosis and Inflammation] 』Springer 、2016
  2. 倉島洋介、清野　宏.『免疫生物学（原書第７版）』南江堂　(翻訳)、2010
  3. 倉島洋介、清野　宏.『免疫学イラストレイテッド（原書第７版）』南江堂 (翻訳)、2009