Welcome to the online home of the Molecular and Tumor Pathology
Mailing Address:
Molecular and Tumor Pathology (E4)
Chiba University Graduate School of Medicine
1-8-1 Inohana, Chuo-ku, Chiba
260-8670 Japan
Contact:
Tel:+81-43-226-2057
Fax:+81-43-226-2058
Overview:
In the department of pathology, definite diagnoses of lesions are made in the clinical medicine setting. Pathologists also play an important role to bridge basic medicine and clinical medicine in modern medical diagnosis and treatment with extensive knowledge in both fields. Therefore, in our department of molecular and tumor pathology, we are performing pathological diagnosis as well as aiming to analyze the nature of lesions by using methods of molecular biology and cellular biology, and to deepen pathological diagnosis by an understanding of the molecular background of lesions. In such a setting, we, in this department, are analyzing the mechanisms of invasion and metastasis of cancer, using methods of molecular and cellular biology and morphology, including molecular imaging, paying attention to interactions between cancer cells and@substrates or cancer cells and surrounding interstitial cells.
Research & Education:
1. Tumor cell biology
@Molecular mechanism of invasion and metastasis of colorectal and breast carcinomas
@Molecular interaction between fragmentedhyaluronan and CD44
Hyaluronan-induced cell motility (activation of RhoGTPases and assembly of cytoskeletons)
Molecular mechanism of epithelial-mesenchymal transition
2. Stem cell biology
Cell-cell and cell-matrix interaction of stem cell (Notch signaling and function of CD44)
3. Signal transduction
Hyaluronan-induced signaling
Notch signaling: function of mastermind (knockout mice)
4. Live cell imaging
5. Human pathology
Recent Publications:
"Reprogramming of natural killer T (NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro."Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, lida-Kobayashi M,
Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Hayigaya K, Keseki H, Taniguchi M. J Clin Inv. 120(7):2610-2618. (2010)
"Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex." Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M. Nature Cell Biol. 12, 278-285. (2010)
"Human Mena associates with Rac1 small GTPase in glioblastoma cell lines." Higashi M, Ishikawa C, Yu J, Toyoda A, Kawana H, Kurokawa K, Matsuda M, Kitagawa, M,Harigaya K. PLoS One.4(3):e4765. (2009)
"CD44 suppresses TLR-mediated inflammation." Kawana H, Karaki H, Higashi M, Miyazaki M, Hilberg F, Kitagawa M, Harigaya K. J Immunol. 180(6):4235-45. (2008)
"Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo." Oyama T, Harigaya K, Muradil A, Hozumi K, Habu S, Oguro H, Iwama A, Matsuno K, Sakamoto R, Sato M, Yoshida N, Kitagawa M. Proc Natl Acad Sci U S A.. 104(23):9764-9. (2007)
Update: 2010.10.01