研究・業績

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論文

2018年〜

1. Taguchi K, Yamagishi SI, Yokoro M, Ito S, Kodama G, Nakayama Y, Ando R, Yamada-Obara N, Asanuma K, Matsui T, Higashimoto Y, Brooks CR, Ueda S, Okuda S, Fukami K. RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice. Sci Rep. Feb 8;8(1):2686. Doi:10.1038/s41598-018-21176-5. 2018

2. Sunahara S,Watanabe E,Hatano M,Swanson PE,Oami T,Fujimura L,Teratake Y,Shimazui T,Lee C,Oda Sl.Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model.Sci Rep.jan 18;8(1):1050.doi:10.1038/s41598-018-19350-w.2018

3. Asao R,Seki T,Takagi M,Yamada H,Kodama F,Hosoe-Nagai Y,Tanaka E,Trejo JAO,Yamamoto-Nonaka K,Sasaki Y,Hidaka T,Ueno T,Yanagita M,Suzuki Y,Tomino Y,Asanuma K.Racl in podocytes promotes glomerular repair and limits the formation of sclerosis Sci Rep.Mar22;8(1):5061.doi:10.1038/s41598-018-23278-6.2018

4. Kudo A,Shirato I,Hidaka T,Takagi M,Sasaki Y,Asanuma K,Ishidoh K,Suzuki Y.Exprrssion of cathepsin L and its intrinsic inhibitors in glomeruli of tats with puromcin aminonnucleoside nephrosis.J Histochem Cytochem.2018 Jul 27:22155418791822.doi:10.1369/0022155418791822

5. Empitu MA,Kadariswantingsih IN,Aizawa M,Asanuma K.MAGI-2 and scaffold proteins in glomerulopathy.Am J Physiol Renal Physiol.Aug15.doi:10.1152/ajprenal.00292.2018

 6. Wang J,Hidaka T,Sasaki Y,Tanaka E,Takagi M,Shibata T,Kudo A,Trejo JAO,Wang L,Asanuma K,Tomino Y.Neurofilament heavy polypeptide protect against reduction in synaptopodin expression and prevents podocyte detachmet.Nov 21;8(1):17157.doi:10.1038/s41598-018-35465-6.Sci Rep.2018

2017年

7. Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Trejo JAO, Miyake T, Yamada H, Campbell K, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K. Mechanism of the glomerulosclerosis induced by MAGI-2 deficiency in kidney podocytes. J Am Soc Nephrol. 28. 2654-2669. 2017

8 Sasaki Y, Hidaka T, Ueno T, Akiba-Takagi M, Trejo JA, Seki T, Nagai-Hosoe Y, Tanaka E, Horikoshi S, Tomino Y, Suzuki Y, Asanuma K. Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte. Sci Rep. Mar 7;7:43921. Doi: 10.1038/srep43921.2017

9. Takagi H, Nishibori Y, Katayama K, Katada T, Takahashi S, Kikuchi Z, Takahashi SI, Kamei H, Kawakami H, Akimoto Y, Kudo A, Asanuma K, Takematsu H, Yan K. UPS40 gene knockdown disrupts glomerular permwability in zebrafish. Am J Physiol Renal Physiol.312. F702-F715. 2017

10. Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N, Ueno T, Nishinakamura R, Tomino Y, Asanuma K. Re-expression of Sall1 in podocytes against Adriamycin induced nephrosis. Lab Invest. doi: 10.1038/labinvest.2017

11. Nakamura N,Taguchi K,Miyazono Y,Uemura K,Koike K,Kurokawa Y,Nakayama Y,Kaida Y,Shibata R,Tsuchimoto A,Asanuma K,Fukami K.AGEs-RAGE overexpression in a patient with smoking-related idiopathic nodular glomerulosclerosis.CEN Case Reports.Nov27.doi:10.1007/s13730-017-0290-1.2017

 

2016年

12. Tsuchida K, Matsusaka T, Ohtcuka M, Miura H, Okuno Y, Asanuma K, Nakagawa T, Yanagita M, Mori K. Establishment of Nephrin Reporter Mice and Use for Chemical Screening. PLoS One. 11: e0157497. Doi: 10.1371/journal.pone.0157497. 2016

13. Ohtsubo H, Okada T, Nozu K, Takaoka Y, Shono A, Asanuma K, Zhang L, Nakanishi K, Taniguchi-Ikeda M, Kaito H, Iijima K, Nakamura S. Identification of mutations in FN1 leading to glomerulopathy with fibronectin deposits. Pediatr Nephrol. 1459-67. 2016

14. Yamada-Obara N, Yamagishi SI, Taguchi K, Kaida Y, Yokoro M, Nakayama Y, Ando R, Asanuma K, Matsui T, Ueda S, Okuda S, Fukami K. Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring. Clin Exp Nephrol. 20. 853-861. 2016

15. Nonaka-Yamamoto K, Koike M, Asanuma K, Akiba-Takagi M, Trejo JAO, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y, Tomino Y. Cathepsin D in podocytes plays an important role in the pathogenesis of proteinuria and chronic kidney disease. J Am Soc Nephrol.  27. 2685-700. 2016

16. Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T. Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy. Diabetes. 65. 755-67. 2016

 

2015年

17. Ozawa S, Ueda S, Imamura H, Mori K, Asanuma K, Yanagita M, Nakagawa T. Glycolysis, but not Mitocohdria, responsible for intracellular ATP distribution in cortical area of podocytes.  Sci Rep. 18. 18575. Doi: 10.1038/srep1857. 2015

18. Ishizaka M, Gohda T, Takagi M, Omote K, Sonoda Y, Trejo JAO, Asano R, Hidaka T, Asanuma K, Horikoshi S, Tomino Y. Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice. Biochem Biophys Res Commu. 467. 549-55. Doi: 10.1016/j.bbrc.2015.09.158. 2015

19. Ueda S, Ozawa S, Mori K, Asanuma K, Yanagita M, Uchida S, Nakagawa T. ENOS deficiency causes podocyte injury with mitochondrial abnormality. Free Radic Biol Med. 87. 181-92. 2015

20. Jeong KH, Asanuma K, Lydia A, Takagi M, Asao R, Kodama F, Asanuma E, Tomino Y. Combination therapy with telmisartan and oxacalcitriol suppresses the progression of murine adriamycin nephropathy. Nephron Exp Nephrol. 129. 143-54. 2015 (K A is corresponding author)

21. Fukuda H, Hidaka T, Takagi-Akiba M, Ichimura K, Trejo JAO, Sasaki Y, Wang J, Sakai T, Asanuma K, Tomino Y. Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor prognosis patients with IgA nephropathy. Cell & Tissue Research 360. 391-400. 2015

22. Wang J, Asanuma K, Hidaka T, Sasaki Y, Yanaka E, Takagi-Akiba M, Trejo JAO, Tomino Y. Newly identified molecules related to podocyte injury induced by Adriamycin. Juntendo Medical Journal. 61.34-40.2015

23. Tanaka E, Asanuma K, Kim EH, Sasaki Y, Trejo JAO, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y. Notch2 activation ameliorates nephrosis. Nature Commun. doi: 10.1038/ncomms4296 2014 (K A is corresponding author)

 

2014年

24. Ihara K, Asanuma K, Fukuda T, Ohwada S, Nishimori K. MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol. 184.2699-708. 2014

25. Seki T, Asanuma K, Asao R, Nonaka K, Sasaki Y, Kurosawa H, Hirayama Y, Horikoshi S, Tomino Y, Saito A. Significance of urinary full-length megalin in patients with IgA nephropathy. PLoS One. DOI:10.1371/journal.pone.0114400. 2014 (T S, K A contributed equally to this publication)

26. Trejo JAO, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.Biochem Biophys Res Commun. 446:1190-6. 2014

 

以下代表的な論文

27. Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y. Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patoents with IgA nephropathy. Nephrol Dial Transplant. 28: 1762-72. 2013 (F K, K A contributed equally to this publication)

28. Asao R, Asanuma K, Kodama F, Akiba-Takagi M, Hosoe-Nagai Y, Seki T, Takeda Y, Ohsawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horikoshi S, Hara M, Tomino Y. Relationships between levels of urinary podocalyxin, number of urinary podocytes and histological injury in adult patients with IgA nephropathy. Clin J Am Soc Nephrol. 7. 1385-93. 2012 (R A, K A contributed equally to this publication)

29. Lydia A, Asanuma K, Nonaka K, Takagi M, Jeong K-H, Kodama F, Asao R, Asanuma E, Prodjosudjadi W, Tomino Y. Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis. Am J Nephrol. 35. 58-68. 2012  (A L, K A contributed equally to this publication)

30. Takagi-Akiba M, Asanuma K, Tanida I, Tada N, Trejo JAO, Nonaka K, Asanuma E, Eiki Kominami E, Ueno T, Tomino Y. Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice. Am J Physiol Renal Physiol. 302. F380-389. 2012

31. Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A, Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanuma E, Kominami E, Ueno T, Tomino Y. Dendrin location in podocytes is associated with the disease progression in animal and human glomerulopathy. Am J Nephrol. 23: 537-549, 2011

32. Asanuma K, Campbell K, Kim KH, Faul C, Mundel P. Nuclear relocation of dendrin, a nephrin and CD2AP binding protein, promotes apoptosis of podocytes. Proc Natl Acad Sci USA. 104. 10134-10139. 2007

33. Yanagida-Asanuma E, Asanuma K, Kim KH, Donnelly M, Choi HY, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol. 171. 415-27. 2007 (E Y-A, K A contributed equally to this publication)

34. Asanuma K,Yanagida-Asanuma E, Tomino Y, Kim KH, Mundel P. Synaptopodin orcheatrates actin organization and cell motility via regulation of RhoA signalling. Nature Cell Biol. 8. 485-491.2006

35. Asanuma K, Kim KH, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P. Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest. 115:1188-1198. 2005

36. Asanuma K, Tanida I, Shirato I, Ueno T, Takahara H, Nishitani T, Kominami E, Tomino Y, MAP-LC3, a promising autophagosomal marker, is processed in the differentiation and recovery of podocytes from a PAN-nephrosis. FASEB J17: 1165-1167, 2003

37. Asanuma K, Shirato I, Ishidoh K, Kominami E, Tomino Y, Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes. Kidney Int.62: 822-831, 2002