Thesis by Dr. Yumi Nakamura ( The 1st Chiba University G-COE Annual Best Research Award winner in 2008) published in 'Immunity'

Critical Role for Mast Cells in

Interleukin-1β-Driven Skin Inflammation Associated

with an Activating Mutation in the Nlrp3 Protein

Yuumi Nakamura,Luigi Franchi,Naotomo Kambe,Guangxun Meng,Warren Strober,and Gabriel Nunez1,*

1Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA

2Department of Dermatology, Chiba University Graduate School of Medicine, Inohana, Chuo-ku, Chiba 260-8670, Japan

3Unit of Innate Immunity, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological

Sciences, Chinese Academy of Sciences, Shanghai, 200025, China

4Mucosal Immunity Section, Laboratory for Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health,

Bethesda, MD 20892, USA

*Correspondence: bclx@umich.edu