Research Achievements
Kan Chiba| 2012 | 2011 | 2010 | 2009 |
| Papers| International Conferences |
Papers
Sano E‚ Li W‚ Yuki H‚ Liu X‚ Furihata T‚ Kobayashi K‚ Chiba K‚ Neya S‚ Hoshino T. Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis.
J. Comput. Chem. 2010; 31 2746-2758
Furihata T‚ Fukuchi Y‚ Iikura M‚ Hashizume M‚ Miyajima A‚ Nagai M‚ Chiba K. Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes
Antimicrob. Agents Chemother. 2010; 54 3035-3038
Kobayashi K‚ Saito K‚ Takagi S‚ Chiba K. Ligand-dependent assembly of pregnane X receptor‚ constitutive androstane receptor and liver X receptor is applicable to identify ligands.
Drug Metabolism Letters 2010; 4 88-94
Saito K.‚ Kobayashi K.‚ Mizuno Y.‚ Furihata T.‚ Chiba K. Constitutive androstane/active receptor is a target of retinoic acid receptor in humans.
Biochem. Pharmacol. 2010; 80 129-135
Saito K.‚ Kobayashi K.‚ Mizuno Y.‚ Fukuchi Y.‚Furihata T.‚ and Chiba K. Peroxisome proliferator-activated receptor alpha (PPARa) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes
Drug Metab. Phamacokinet. 2010; 25 (1): 93-100
Aueviriyavit S.‚Kobayashi K.‚ and Chiba K. Species differences in mechanism-based inactivation of CYP3A among humans‚ rats and mice.
Drug Metab. Phamacokinet. 2010; 25 (1): 93-100
International Conferences
Satoshi Kishida‚ Tomomi Furihata‚ Atsuko Kamiichi‚ Yuki Ohta‚ Kosuke Saito and Kan Chiba HIBMEC/KYAS‚ A NEWLY IMMORTALIZED HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELL LIME‚ IS A PROMISING TOOL FOR AN IN VITRO BLOOD-BRAIN BARRIER MODEL
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Seiya Ishii‚ Tomomi Furihata‚ Minami Iikura‚ Yukina Fukuchi‚ Misato Hashizume ‚ Miki Nagai and Kan Chiba CHARACTERIZATION OF THE NOVEL TISSUE-SPECIFIC PROMOTER OF THE SLC29A1 GENE
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Tomomi Furihata‚ Yukina Fukuchi‚ Minami Iikura‚ Misato Hashizume and Kan Chiba HUMAN HEPATIC RIVABIRIN TRASPORTER：MOLECULAR CHARACTERIZATION AND EXPRESSION PROFILE IN HEPATOCYTES
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Akane Yoshida‚ Kaoru Kobayashi‚ Yoko Ejiri‚ Sachiko Takagi‚ Hanaka Mimura‚ Masaya Hosoda and Kan Chiba INDUCED EXPESSIONS AND ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN THE HUMAN HEPATOCELLULAR CARCINOMA CELL LINE CULTURED ON THE MICRO-SPACE CELL CULTURE PLATES
9th Interntional ISSX Meeting （第9回国際薬物動態学会） 2010-9-4 Istanbul/Turkey
Yasuko Tsukazaki‚ Manabu Nishi‚ Naoto Senda‚ Kazuki Yasuhiro‚ Kinya Kubo‚ Kaoru Kobayashi‚ Kan Chiba‚ Shigeru Yamada‚ Tetsuo Kokji‚ Masakazu Takahashi‚ Hiroshi Igarashi and Mistuo Oshimura HUMANIZED CYP3A MICE：（3）METABOLISM OF CYP3A4 SUBSTRATES DETECTED BY LC/MS SYSTEM
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Yasuhiro Kazuki‚ Satoshi Abe‚ Masato Takiguchi‚ Hidetoshi Hoshiya‚ Naoya Kajitani‚ Toko Yoshino‚ Shoko Takehara‚ Chie Ishihara‚ Kinya Kubo ‚ Takeshi Oshima‚ Kazuma Tomizuka‚ Sasitorn Aueviyavit‚ Kaoru Kobayashi‚ Kan Chiba‚ Yasuko Tsukazaki‚ Naoto Senda and Mistuo Oshimura HUMANIZED CYP3A MICE ：(1)CONSTRUCTION OF HUMANIZED MODEL MICE CONTAINING THE CYP3A CLUSTER FOR DRUG SCREENING
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Miki Nagai‚ Tomomi Furihata‚ Sayaka Matsumoto‚ Seiya Ishii and Kan Chiba A NOVEL MRNA SPLICING ISOFORM IS A REAL CANCER-TYPE ORGANIC ANION TRANPORTING POLYPEPTIDE 1B3 MRNA
9th Interntional ISSX Meeting （第9回国際薬物動態学会） 2010-9-4 Istanbul/Turkey
Minami Iikura‚Tomomi Furihata‚ Masanori Ikeda‚ Nobuyuki Kato and Kan Chiba RIBAVIRIN UPTAKE SYSTEMS ARE REQUIGED FOR THE ANITI–HEPATITIS C VIRUS ACTIVITY OF RIBAVIRIN
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
Mio Watanabe‚ Sasitorn Aueviriyavit‚ Kaoru Kobayashi‚ Nahoko Iuchi‚ Yasuhiro Kazuki‚ Mitsuo Oshimura and Kan Chiba HUMANIZED CYP3A MICE: (2) FUNCTIONAL EXPRESSION OF HUMAN CYP3A ISOFORMS IN CYP3A-HAC MICE AND INHIBITION OF CYP3A VIA MECHHANISM –BASED INACTIVATION
9th Interntional ISSX Meeting 2010-9-4 Istanbul/Turkey
