Research Achievements
Toshiharu Horie| 2012 | 2011 | 2010 | 2009 | 2008 |
	
		| Papers| Books |
Papers
Hamada‚ K.‚ Shitara‚ Y.‚ Sekine‚ S.‚ and Horie‚ T.   Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.
				Cancer Chemother. Pharmacol.  2010;   66   (6):   1031-1038  
Yano‚ K.‚ Sekine‚ S.‚ Nemoto‚ K.‚ Fuwa‚ T.‚ and Horie‚ T.   The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat.
				Biochem. Pharmacol.  2010;   80   (4):   533-539  
Sekine‚ S.‚ Yano‚ K.‚ Saeki‚ J.‚ Hashimoto‚ N.‚ Fuwa‚ T.‚ and Horie‚ T.   Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.
				Biochem. Biophys. Res. Commun.  2010;   399   (2):   279-285  
Okuda‚ T.‚ Norioka‚ M.‚ Shitara‚ Y.‚ and Horie‚ T.   Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition.
				Toxicol. Appl. Pharmacol.  2010;   248   (3):   242-248  
Doi‚ H.‚  and Horie‚ T.   Salicylic acid-induced hepatotoxicity triggered by oxidative stress.
				Chem Biol Interact.  2010;   183   (3):   363-368  
Moriyama‚ T.‚ Kemi‚ M.‚ Okumura‚ C.‚ and Yoshihara‚ K.‚ Horie‚ T.   Involvement of advanced glycation end-products‚ pentosidine and N(epsilon)-(carboxymethyl)lysine‚ in doxorubicin-induced cardiomyopathy in rats.
				Toxicology  2010;   31   (1-2):   89-97  
Books
Maeda‚ K.‚ Shitara‚ Y.‚ Horie‚ T.‚ £á£î£ä Sugiyama‚ Y. (Eds.: Pang‚ S.K.‚ Rodrigues‚A.D.‚ and Peter‚ R.M.) ¡¡ Web-based database as a tool to examine drug-drug interactions involving transporters Enzyme- and Transporter-Based Drug-Drug Interactions (Springer) 2010; 387-412
Kato‚ M.‚ Shitara‚ Y.Kitajima‚ M.‚ Tachibana‚ T.‚ Ishigaki‚ M.‚ Horie‚ T.‚ and Sugiyama‚ Y. (Eds.: Pang‚ S.K.‚ Rodrigues‚A.D.‚ and Peter‚ R.M.) ¡¡ Extrapolation of in vitro matabolic and P-glycoprotein-mediated transport data to in vivo by modeling and simulations Enzyme- and Transporter-Based Drug-Drug Interactions (Springer) 2010; 299-315

