Research Achievements
Issei Komuro| 2012 | 2011 | 2010 | 2009 | 2008 |
	
		| Papers| International Conferences |
Papers
Ishii G‚ Hashimoto H‚ Asada K‚ Ito T‚ Hoshino A‚ Fujii S‚ Kojima M‚ Kuwata T‚ Harigaya K‚ Nagai K‚ Ushijima T‚ Ochiai A.   Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts.
				Int J Oncol.  2010;   37   (2):   317-325  
Shimizu I‚ Minamino T‚ Toko H‚ Okada S‚ Ikeda H‚ Yasuda N‚ Tateno K‚ Moriya J‚ Yokoyama M‚ Nojima A‚ Koh GY‚ Akazawa H‚ Shiojima I‚ Kahn CR‚ Abel ED‚ Komuro I.   Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
				J Clin Invest.  2010;   20   (5):   1506-1514  
Naito AT‚ Okada S‚ Minamino T‚ Iwanaga K‚ Liu ML‚ Sumida T‚ Nomura S‚ Sahara N‚ Mizoroki T‚ Takashima A‚ Akazawa H‚ Nagai T‚ Shiojima I‚ Komuro I.   Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury.
				Circ Res.  2010;   106   (11):   1692-1702  
Ono H‚ Funabashi N‚ Uehara M‚ Yajima R‚ Kataoka A‚ Ueda M‚ Miyauchi H‚ Daimon M‚ Takaoka H‚ Komuro I.   Comprehensive evaluation of characteristics of left ventricular myocardium in a subject with non-coronary arterial cardiac dysfunction through segment by segment analysis using various diagnostic modalities.
				Int J Cardiol.  2010;   145   (1):   95-100  
Yoshida N‚ Funabashi N‚ Uehara M‚ Yajima R‚ Kataoka A‚ Ueda M‚ Takaoka H‚ Komuro I.   Differentiation of diagnosis and prognoses of non-coronary arterial primary myocardial diseases with left ventricular focal myocardial thinning evaluated by multislice computed tomography.
				Int J Cardiol.  2010;   145   (2):   277-281  
Takaoka H‚ Takano H‚ Nakagawa K‚ Kobayashi Y‚ Hiroshima K‚ Komuro I.   Buerger”Ēs disease-like vasculitis associated with Kimura”Ēs disease.
				Int J Cardiol.  2010;   140   (2):   e23-26  
Ishio N‚ Kobayashi Y‚ Iwata Y‚ Kitahara H‚ Fukushima K‚ Asano T‚ Nakayama T‚ Kuroda N‚ Komuro I.   Ubiquitous atherosclerosis in coronary arteries without angiographically significant stenosis.
				Heart Vessels  2010;   25   (1):   35-40  
Fukushima K‚ Kobayashi Y‚ Kitahara H‚ Iwata Y‚ Kuroda N‚ Ooyama M‚ Kuwabara Y‚ Nomura F‚ Komuro I   Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study.
				Heart Vessels  2010;   25   (1):   41-44  
Kawakubo M‚ Funabashi N‚ Takahashi M‚ Sueishi M‚ Motoyoshi Y‚ Mikata T‚ Uchida I‚ Asakawa T‚ Takahashi R‚ Takamatsu M‚ Matsuoka Y‚ Minegishi M‚ Naga H‚ Yajima R‚ Kataoka A‚ Lee K‚ Komuro I.   Relationship of natriuretic peptide and transthoracic echocardiographic findings in 135 subjects with muscular dystrophy.
				Int J Cardiol.  2010;   145   (3):   506-514  
Sawada T‚ Minamino T‚ Fu HY‚ Asai M‚ Okuda K‚ Isomura T‚ Yamazaki S‚ Asano Y‚ Okada KI‚ Tsukamoto O‚ Sanada S‚ Asanuma H‚ Asakura M‚ Takashima S‚ Kitakaze M‚ Komuro I.   X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.
				J Mol Cell Cardiol.  2010;   48   (6):   1280-1289  
Nakaoka Y‚ Shioyama W‚ Kunimoto S‚ Arita Y‚ Higuchi K‚ Yamamoto K‚ Fujio Y‚ Nishida K‚ Kuroda T‚ Hirota H‚ Yamauchi-Takihara K‚ Hirano T‚ Komuro I‚ Mochizuki N.   SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
				J Mol Cell Cardiol.  2010;   49   (2):   157-164  
Moriya‚ J.‚ Minamino‚ T.‚ Tateno‚ K.‚ Okada‚ S.‚ Uemura‚ A.‚ Shimizu‚ I.‚ Yokoyama‚ M.‚ Nojima‚ A.‚ Okada‚ M.‚ Koga‚ H.‚ Komuro‚ I   Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis
				Circ Res  2010;   106      391-398  
Obana M‚ Maeda M‚ Takeda K‚ Hayama A‚ Mohri T‚ Yamashita T‚ Nakaoka Y‚ Komuro I‚ Takeda K‚ Matsumiya G‚ Azuma J‚ Fujio Y.   Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.
				Circulation  2010;   121   (5):   684-691  
Yoshida M‚ Oh H.   Stem Cell Engineering for Cardiac Tissue Regeneration.
				Cardiology  2010;   115   (3):   191-193  
Liao CH‚ Akazawa H‚ Tamagawa M‚ Ito K‚ Yasuda N‚ Kudo Y‚ Yamamoto R‚ Ozasa Y‚ Fujimoto M‚ Wang P‚ Nakauchi H‚ Nakaya H‚ Komuro I.   Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded hearts.
				J Clin Invest.  2010;   120   (1):   242-253  
Nakayama T‚ Komiyama N‚ Yokoyama M‚ Namikawa S‚ Kuroda N‚ Kobayashi Y‚ Komuro I.   Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: A randomized prospective study using intravascular ultrasound.
				Int J Cardiol.  2010;   138   (2):   157-165  
Shimizu I‚ Iguchi N‚ Watanabe H‚ Umemura J‚ Tobaru T‚ Asano R‚ Misu K‚ Nagayama M‚ Aikawa M‚ Funabashi N‚ Komuro I‚ Sumiyoshi T.   Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.
				Int J Cardiol.  2010;   142   (3):   224-229  
Murayama T‚ Funabashi N‚ Uehara M‚ Takaoka H‚ Komuro I.   New classification of aortic dissection during the cardiac cycle as pulsating type and static type evaluated by electrocardiogram-gated multislice CT.
				Int J Cardiol.  2010;   142   (2):   177-186  
Sekine T‚ Daimon M‚ Hasegawa R‚ Toyoda T‚ Kawata T‚ Funabashi N‚ Komuro I.   The impact of sleep deprivation on the coronary circulation.
				Int J Cardiol.  2010;   144   (2):   266-267  
Hori Y‚ Funabashi N‚ Uehara M‚ Ueda M‚ Takaoka H‚ Nakamura K‚ Murayama T‚ Komuro I.   Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis.
				Int J Cardiol.  2010;   142   (2):   152-158  
International Conferences
Ito‚ K. Cardiac Mast Cells Cause Atrial Fibrillation in Angitensin II-infused Hearts 
				Basic Cardiovascular Sciences Conference 2010 2010-7-19 California/USA
Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Activation of b-catenin signaling by macrophage-derived MMP-9 is critical for AngII-induced vascular remodeling 
				Basic Cardiovascular Sciences 2010 2010-7-19 Los Angeles CA‚/USA
Komuro I 2010Angiotensin Gordon Conference 
				Molecular & Therapeutic implications of””stretch-sensing by the AT1R 2010-2-21 California/U.S.A.
Ito‚ K. Cardiac Mast Cells Cause Atrial Fibrillation in Angitensin II-infused Hearts 
				American Heart Association Scientic Sessions 2010 2010-11-13 Chicago/USA
Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Activation of b-catenin signaling by macrophage-derived factor is critical for Angiotensin II-induced vascular remodeling 
				AHA scientific sessions 2010 2010-11-13 Chicago IL/USA
Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Macrophage-derived factor induce smooth muscle cell proliferation through activation of -catenin signaling and plays a pivotal role in arterial remodeling evoked by Angiotensin II 
				Europe Wnt meeting 2010 2010-10-27 Stockholm/Sweden

