Research Achievements

Issei Komuro

2012 | 2011 | 2010 | 2009 | 2008 |
| Papers| International Conferences |

Papers

Ishii G‚ Hashimoto H‚ Asada K‚ Ito T‚ Hoshino A‚ Fujii S‚ Kojima M‚ Kuwata T‚ Harigaya K‚ Nagai K‚ Ushijima T‚ Ochiai A.   Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts.
Int J Oncol.  2010;  37   (2):   317-325


Shimizu I‚ Minamino T‚ Toko H‚ Okada S‚ Ikeda H‚ Yasuda N‚ Tateno K‚ Moriya J‚ Yokoyama M‚ Nojima A‚ Koh GY‚ Akazawa H‚ Shiojima I‚ Kahn CR‚ Abel ED‚ Komuro I.   Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
J Clin Invest.  2010;  20   (5):   1506-1514


Naito AT‚ Okada S‚ Minamino T‚ Iwanaga K‚ Liu ML‚ Sumida T‚ Nomura S‚ Sahara N‚ Mizoroki T‚ Takashima A‚ Akazawa H‚ Nagai T‚ Shiojima I‚ Komuro I.   Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury.
Circ Res.  2010;  106   (11):   1692-1702


Ono H‚ Funabashi N‚ Uehara M‚ Yajima R‚ Kataoka A‚ Ueda M‚ Miyauchi H‚ Daimon M‚ Takaoka H‚ Komuro I.   Comprehensive evaluation of characteristics of left ventricular myocardium in a subject with non-coronary arterial cardiac dysfunction through segment by segment analysis using various diagnostic modalities.
Int J Cardiol.  2010;  145   (1):   95-100


Yoshida N‚ Funabashi N‚ Uehara M‚ Yajima R‚ Kataoka A‚ Ueda M‚ Takaoka H‚ Komuro I.   Differentiation of diagnosis and prognoses of non-coronary arterial primary myocardial diseases with left ventricular focal myocardial thinning evaluated by multislice computed tomography.
Int J Cardiol.  2010;  145   (2):   277-281


Takaoka H‚ Takano H‚ Nakagawa K‚ Kobayashi Y‚ Hiroshima K‚ Komuro I.   Buerger”Ēs disease-like vasculitis associated with Kimura”Ēs disease.
Int J Cardiol.  2010;  140   (2):   e23-26


Ishio N‚ Kobayashi Y‚ Iwata Y‚ Kitahara H‚ Fukushima K‚ Asano T‚ Nakayama T‚ Kuroda N‚ Komuro I.   Ubiquitous atherosclerosis in coronary arteries without angiographically significant stenosis.
Heart Vessels  2010;  25   (1):   35-40


Fukushima K‚ Kobayashi Y‚ Kitahara H‚ Iwata Y‚ Kuroda N‚ Ooyama M‚ Kuwabara Y‚ Nomura F‚ Komuro I   Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study.
Heart Vessels  2010;  25   (1):   41-44


Kawakubo M‚ Funabashi N‚ Takahashi M‚ Sueishi M‚ Motoyoshi Y‚ Mikata T‚ Uchida I‚ Asakawa T‚ Takahashi R‚ Takamatsu M‚ Matsuoka Y‚ Minegishi M‚ Naga H‚ Yajima R‚ Kataoka A‚ Lee K‚ Komuro I.   Relationship of natriuretic peptide and transthoracic echocardiographic findings in 135 subjects with muscular dystrophy.
Int J Cardiol.  2010;  145   (3):   506-514


Sawada T‚ Minamino T‚ Fu HY‚ Asai M‚ Okuda K‚ Isomura T‚ Yamazaki S‚ Asano Y‚ Okada KI‚ Tsukamoto O‚ Sanada S‚ Asanuma H‚ Asakura M‚ Takashima S‚ Kitakaze M‚ Komuro I.   X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.
J Mol Cell Cardiol.  2010;  48   (6):   1280-1289


Nakaoka Y‚ Shioyama W‚ Kunimoto S‚ Arita Y‚ Higuchi K‚ Yamamoto K‚ Fujio Y‚ Nishida K‚ Kuroda T‚ Hirota H‚ Yamauchi-Takihara K‚ Hirano T‚ Komuro I‚ Mochizuki N.   SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
J Mol Cell Cardiol.  2010;  49   (2):   157-164


Moriya‚ J.‚ Minamino‚ T.‚ Tateno‚ K.‚ Okada‚ S.‚ Uemura‚ A.‚ Shimizu‚ I.‚ Yokoyama‚ M.‚ Nojima‚ A.‚ Okada‚ M.‚ Koga‚ H.‚ Komuro‚ I   Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis
Circ Res  2010;  106     391-398


Obana M‚ Maeda M‚ Takeda K‚ Hayama A‚ Mohri T‚ Yamashita T‚ Nakaoka Y‚ Komuro I‚ Takeda K‚ Matsumiya G‚ Azuma J‚ Fujio Y.   Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.
Circulation  2010;  121   (5):   684-691


Yoshida M‚ Oh H.   Stem Cell Engineering for Cardiac Tissue Regeneration.
Cardiology  2010;  115   (3):   191-193


Liao CH‚ Akazawa H‚ Tamagawa M‚ Ito K‚ Yasuda N‚ Kudo Y‚ Yamamoto R‚ Ozasa Y‚ Fujimoto M‚ Wang P‚ Nakauchi H‚ Nakaya H‚ Komuro I.   Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded hearts.
J Clin Invest.  2010;  120   (1):   242-253


Nakayama T‚ Komiyama N‚ Yokoyama M‚ Namikawa S‚ Kuroda N‚ Kobayashi Y‚ Komuro I.   Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: A randomized prospective study using intravascular ultrasound.
Int J Cardiol.  2010;  138   (2):   157-165


Shimizu I‚ Iguchi N‚ Watanabe H‚ Umemura J‚ Tobaru T‚ Asano R‚ Misu K‚ Nagayama M‚ Aikawa M‚ Funabashi N‚ Komuro I‚ Sumiyoshi T.   Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.
Int J Cardiol.  2010;  142   (3):   224-229


Murayama T‚ Funabashi N‚ Uehara M‚ Takaoka H‚ Komuro I.   New classification of aortic dissection during the cardiac cycle as pulsating type and static type evaluated by electrocardiogram-gated multislice CT.
Int J Cardiol.  2010;  142   (2):   177-186


Sekine T‚ Daimon M‚ Hasegawa R‚ Toyoda T‚ Kawata T‚ Funabashi N‚ Komuro I.   The impact of sleep deprivation on the coronary circulation.
Int J Cardiol.  2010;  144   (2):   266-267


Hori Y‚ Funabashi N‚ Uehara M‚ Ueda M‚ Takaoka H‚ Nakamura K‚ Murayama T‚ Komuro I.   Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis.
Int J Cardiol.  2010;  142   (2):   152-158


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International Conferences

Ito‚ K. Cardiac Mast Cells Cause Atrial Fibrillation in Angitensin II-infused Hearts 
Basic Cardiovascular Sciences Conference 2010 2010-7-19 California/USA


Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Activation of b-catenin signaling by macrophage-derived MMP-9 is critical for AngII-induced vascular remodeling 
Basic Cardiovascular Sciences 2010 2010-7-19 Los Angeles CA‚/USA


Komuro I 2010Angiotensin Gordon Conference 
Molecular & Therapeutic implications of””stretch-sensing by the AT1R 2010-2-21 California/U.S.A.


Ito‚ K. Cardiac Mast Cells Cause Atrial Fibrillation in Angitensin II-infused Hearts 
American Heart Association Scientic Sessions 2010 2010-11-13 Chicago/USA


Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Activation of b-catenin signaling by macrophage-derived factor is critical for Angiotensin II-induced vascular remodeling 
AHA scientific sessions 2010 2010-11-13 Chicago IL/USA


Tomokazu Sumida‚ Atsuhiko T. Naito‚ Toshio Nagai‚ Ichiro Shiojima‚ and Issei Komuro Macrophage-derived factor induce smooth muscle cell proliferation through activation of -catenin signaling and plays a pivotal role in arterial remodeling evoked by Angiotensin II 
Europe Wnt meeting 2010 2010-10-27 Stockholm/Sweden


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