Research Achievements
Issei Komuro| 2012 | 2011 | 2010 | 2009 | 2008 |
	
		| Papers| International Conferences |
Papers
Ma H‚ Gong H‚ Chen Z‚ Liang Y‚ Yuan J‚ Zhang G‚ Wu J‚ Ye Y‚ Yang C‚ Nakai A‚ Komuro I‚ Ge J‚ Zou Y.   Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury.
				J Mol Cell Cardiol  2012;           
Iwashita M‚ Sakoda H‚ Kushiyama A‚ Fujishiro M‚ Ohno H‚ Nakatsu Y‚ Fukushima T‚ Kumamoto S‚ Tsuchiya Y‚ Kikuchi T‚ Kurihara H‚ Akazawa H‚ Komuro I‚ Kamata H‚ Nishimura F‚ Asano T.   Valsartan‚ independently of AT1 receptor or PPAR¦Ã‚ suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
				Am J Physiol Endocrinol Metab  2012;   302      E286-296  
Fukushima N‚ Matsuura K‚ Akazawa H‚ Honda A‚ Nagai T‚ Takahashi T‚ Seki A‚ Murasaki KM‚ Shimizu T‚ Okano T‚ Hagiwara N‚ Komuro I.   A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure.
				PLoS One  2012;   6e27901        
Yasuda N‚ Akazawa H‚ Ito K‚ Shimizu I‚ Kudo-Sakamoto Y‚ Yabumoto C‚ Yano M‚ Yamamoto R‚ Ozasa Y‚ Minamino T‚ Naito AT‚ Oka T‚ Shiojima I‚ Tamura K‚ Umemura S‚ Nemer M‚ Komuro I.   Agonist-Independent Constitutive Activity of Angiotensin II Receptor Promotes Cardiac Remodeling in Mice.
				Hypertension  2012;           
Sakata Y‚ Nakatani D‚ Shimizu M‚ Suna S‚ Usami M‚ Matsumoto S‚ Hara M‚ Sumitsuji S‚ Kawano S‚ Iwakura K‚ Hamasaki T‚ Sato H‚ Nanto S‚ Hori M‚ Komuro I.   Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction.
				J Cardiol  2012;   59      14-21  
Okada S‚ Yokoyama M‚ Toko H‚ Tateno K‚ Moriya J‚ Shimizu I‚ Nojima A‚ Ito T‚ Yoshida Y‚ Kobayashi Y‚ Katagiri H‚ Minamino T‚ Komuro I   Brain-Derived Neurotrophic Factor Protects Against Cardiac Dysfunction After Myocardial Infarction via a Central Nervous System-Mediated Pathway.
				Arterioscler Thromb Vasc Biol.  2012;   in press        
Naito AT‚ Sumida T‚ Nomura S‚ Liu ML‚ Higo T‚ Nakagawa A‚ Okada K‚ Sakai T‚ Hashimoto A‚ Hara Y‚ Shimizu I‚ Zhu W‚ Toko H‚ Katada A‚ Akazawa H‚ Oka T‚ Lee JK‚ Minamino T‚ Nagai T‚ Walsh K‚ Kikuchi A‚ Matsumoto M‚ Botto M‚ Shiojima I‚ Komuro I   Complement c1q activates canonical wnt signaling and promotes aging-related phenotypes.
				Cell Metab  2012;   149   (6):   1298-1313  
Kameda Y‚ Hasegawa H‚ Kubota A‚ Tadokoro H‚ Kobayashi Y‚ Komuro I‚ Takano H.   Effects of pitavastatin on pressure overload-induced heart failure in mice.
				Circ J.  2012;   76   (5):   1159-1168  
Uchiyama R‚ Hasegawa H‚ Kameda Y‚ Ueda K‚ Kobayashi Y‚ Komuro I‚ Takano H.   Role of regulatory T cells in atheroprotective effects of granulocyte colony-stimulating factor.
				J Mol Cell Cardiol  2012;   52   (5):   1038-1047  
Hasegawa H‚ Takano H‚ Kameda Y‚ Kubota A‚ Kobayashi Y‚ Komuro I.   Effect of switching from telmisartan‚ valsartan‚ olmesartan‚ or losartan to candesartan on morning hypertension.
				Clin Exp Hypertens.  2012;   34   (2):   86-91  
Shimizu I‚ Yoshida Y‚ Katsuno T‚ Tateno K‚ Okada S‚ Moriya J‚ Yokoyama M‚ Nojima A‚ Ito T‚ Zechner R‚ Komuro I‚ Kobayashi Y‚ Minamino T.   p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure.
				Cell Metab  2012;   15   (1):   51-64  
International Conferences
Issei Komuro Wnts in development in other pathways¡ÈComplement C1q activates canonical Wnt signaling and¡¡Promotes aging-related phenotypes 
				EMBO Conference : 30 Years of Wnt Signalling 2012-6-27 Egmond aan Zee/Netherlands
Issei Komuro Angiogenesis and heart failure 
				17th International Vascular Biology Meeting 2012-6-2 Wiesbaden/Germany
Ito. T CDC42 and NF¦ÊB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells 
				41st Annual Meeting of The American Aging Association 2012-5-31 Dallas/USA
Ito. T CDC42 and NF¦ÊB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells 
				Keystone Symposia symposium:Molecular Basis of Vascular Inflammation and Atherosclerosis (C7) 2012-3-25 Big Sky/USA
Yoshida Y‚ Minamino T Notch signaling positively regulates vascular endothelial cell senescence 
				Gordon Research Conference‚ Aging‚ Biology of 2012-2-12 Ventura/USa

